首页|Nucleus-targeting orange-emissive carbon dots delivery adriamycin for enhanced anti-liver cancer therapy

Nucleus-targeting orange-emissive carbon dots delivery adriamycin for enhanced anti-liver cancer therapy

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Carbon dots(CDs)with precise targeting function show great potential in the field of drug delivery thera-peutics.In this study,the functionalized nucleus-targeting orange-emissive CDs with nuclear localization sequence(NLS)were loaded with adriamycin(DOX)to obtain a nucleus-targeting orange-emissive CDs drug delivery system(CDs-NLS-DOX),which delivered DOX to tumor cell nuclei to enhance its anti-tumor activity.The drug carrier orange-emissive CDs showed excitation-independent behavior,stable and en-hanced imaging capability and good biocompatibility in vitro and in vivo.Meanwhile,the CDs-NLS could target the nuclei efficiently,and the CDs-NLS-DOX complexes had a high drug loading rate(59.4％)after loading DOX,exhibiting pH-dependent DOX release behavior through breaking acylhydrazone bond in a weak acidic environment.In addition,the CDs-NLS-DOX complexes exhibited an enhanced killing activity against human hepatoma cells(HepG2).The in vivo therapeutic effects on HepG2 nude mice transplanted tumors indicated the CDs-NLS-DOX had a stronger ability to inhibit tumor growth compared to free DOX.In short,CDs-NLS-DOX is expected to be a precise and efficient nucleus-targeting nano-drug delivery sys-tem for tumor treatment.

Carbon dotsNucleus-targetingAdriamycinDrug delivery systemLiver cancer therapy

Qiang Li、Jiangbo Fan、Hongkai Mu、Lin Chen、Yongzhen Yang、Shiping Yu

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The Second Hospital of Shanxi Medical University,Taiyuan 030001,China

Shanxi Medical University,Taiyuan 030001,China

Key Laboratory of Interface Science and Engineering in Advanced Materials,Ministry of Education,Taiyuan University of Technology,Taiyuan 030024,China

Shanxi-Zheda Institute of Advanced Materials and Chemical Engineering,Taiyuan 030032,China

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National Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaScientific Research Project of Shanxi Provincial Health CommissionShanxi-Zheda Institute of Advanced Materials and Chemical EngineeringShanxi Center of Technology Innovation for Controlled and Sustained Release of NanodrugsFoundational Research Project of Shanxi ProvinceFour"Batches"Innovation Project of Invigorating Medical through Science and Technology of Shanxi ProvinceShanxi Scholarship Council of China

82172048U21A2037820231202021SX-FR0102021040109110262022030212111592023XM0122022-039

2024

10.1016/j.cclet.2023.108947

中国化学快报(英文版)
中国化学会

中国化学快报(英文版)

CSTPCD
影响因子：0.771
ISSN：1001-8417
年,卷(期)：2024.35(6)
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