Nucleus-targeting orange-emissive carbon dots delivery adriamycin for enhanced anti-liver cancer therapy

Qiang Li ¹Jiangbo Fan ²Hongkai Mu ²Lin Chen ³Yongzhen Yang ³Shiping Yu²

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作者信息

1. The Second Hospital of Shanxi Medical University,Taiyuan 030001,China;Shanxi Medical University,Taiyuan 030001,China
2. Shanxi Medical University,Taiyuan 030001,China
3. Key Laboratory of Interface Science and Engineering in Advanced Materials,Ministry of Education,Taiyuan University of Technology,Taiyuan 030024,China;Shanxi-Zheda Institute of Advanced Materials and Chemical Engineering,Taiyuan 030032,China
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Abstract

Carbon dots(CDs)with precise targeting function show great potential in the field of drug delivery thera-peutics.In this study,the functionalized nucleus-targeting orange-emissive CDs with nuclear localization sequence(NLS)were loaded with adriamycin(DOX)to obtain a nucleus-targeting orange-emissive CDs drug delivery system(CDs-NLS-DOX),which delivered DOX to tumor cell nuclei to enhance its anti-tumor activity.The drug carrier orange-emissive CDs showed excitation-independent behavior,stable and en-hanced imaging capability and good biocompatibility in vitro and in vivo.Meanwhile,the CDs-NLS could target the nuclei efficiently,and the CDs-NLS-DOX complexes had a high drug loading rate(59.4％)after loading DOX,exhibiting pH-dependent DOX release behavior through breaking acylhydrazone bond in a weak acidic environment.In addition,the CDs-NLS-DOX complexes exhibited an enhanced killing activity against human hepatoma cells(HepG2).The in vivo therapeutic effects on HepG2 nude mice transplanted tumors indicated the CDs-NLS-DOX had a stronger ability to inhibit tumor growth compared to free DOX.In short,CDs-NLS-DOX is expected to be a precise and efficient nucleus-targeting nano-drug delivery sys-tem for tumor treatment.

Key words

Carbon dots/Nucleus-targeting/Adriamycin/Drug delivery system/Liver cancer therapy

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基金项目

National Natural Science Foundation of China(82172048)

National Natural Science Foundation of China(U21A20378)

Scientific Research Project of Shanxi Provincial Health Commission(2023120)

Shanxi-Zheda Institute of Advanced Materials and Chemical Engineering(2021SX-FR010)

Shanxi Center of Technology Innovation for Controlled and Sustained Release of Nanodrugs(202104010911026)

Foundational Research Project of Shanxi Province(202203021211159)

Four"Batches"Innovation Project of Invigorating Medical through Science and Technology of Shanxi Province(2023XM012)

Shanxi Scholarship Council of China(2022-039)

出版年

2024

中国化学快报(英文版)

中国化学会

中国化学快报(英文版)

CSTPCD

影响因子：0.771

ISSN：1001-8417

参考文献量2

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