首页|Worm-like micelles facilitate the intestinal mucus diffusion and drug accumulation for enhancing colorectal cancer therapy

Worm-like micelles facilitate the intestinal mucus diffusion and drug accumulation for enhancing colorectal cancer therapy

扫码查看
原文链接
  • NETL
  • NSTL
  • 万方数据
Local delivery of nanoparticles holds promise for colorectal cancer(CRC)therapy.However,the pres-ence of the mucus layer on the epithelium poses a significant challenge to drug delivery,thereby ad-versely affecting treatment efficiency.It is crucial to develop efficient drug delivery carriers that can effectively overcome mucus barriers to treat colorectal cancer.Herein,we utilized poly(1,4-butadiene)-b-poly(ethylene oxide)polymers to prepare four distinct geometries of polymeric micelles,namely linear micelles(LMs),worm-like micelles(WLMs),large spherical micelles(LSMs),and small spherical micelles(SSMs)to investigate the influence of shape effects on overcoming colonic mucosal barrier.We found that the carriers exhibited diverse shapes while maintaining comparable physicochemical properties.Of these,WLMs had an aspect ratio similar to segmented filamentous bacteria,which exhibited superior mucus penetration ability,leading to prolonged drug release kinetics and faster entry into epithelial cells com-pared to LSMs.Furthermore,rectally administrated 10-hydroxycamptothecin-loaded WLMs traversed the colorectal mucus in orthotopic CRC nude mice model,penetrated and accumulated within tumor tissue,and effectively aggregated within cancer cells,thereby inducing significantly robust antitumor outcomes in vivo.These findings underscore the significance of shape design in overcoming colonic mucosal absorp-tion barriers,offering a novel approach for the development of drug delivery carriers tailored for effective tumor therapy.

Worm-like micellesMucus penetrationShape dependentTransmucosal deliveryColorectal cancer

Yihan Zhou、Duo Gao、Yaying Wang、Li Liang、Qingyu Zhang、Wenwen Han、Jie Wang、Chunliu Zhu、Xinxin Zhang、Yong Gan

展开 >

State Key Laboratory of Drug Research and Center of Pharmaceutics,Shanghai Institute of Materia Medica,Chinese Academy of Sciences,Shanghai 201203,China

School of Chinese Materia Medica,Nanjing University of Chinese Medicine,Nanjing 210023,China

University of Chinese Academy of Sciences,Beijing 100049,China

School of Pharmacy,Shanghai University of Traditional Chinese Medicine,Shanghai 201203,China

NMPA Key Laboratory for Quality Research and Evaluation of Pharmaceutical Excipients,National Institutes for Food and Drug Control,Beijing 100050,China

展开 >

National Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaChinese Pharmacopoeia Commission

8200367882222066820250322021Y30

2024

10.1016/j.cclet.2023.108967

中国化学快报(英文版)
中国化学会

中国化学快报(英文版)

CSTPCD
影响因子：0.771
ISSN：1001-8417
年,卷(期)：2024.35(6)
  • 1