Abstract
Introducing heavy halogen atoms into organic small molecules is a practical strategy for efficient sin-glet oxygen(1O2)generation.Generally,bromine or iodine atoms are introduced on the aza-boron-dipyrromethene(aza-BODIPY)core,rather than on the periphery aryl rings for efficient 1O2 generation.Herein,an aza-BODIPY dye NBDPBr with unexpected bromination on the periphery aryl rings was synthe-sized for photoacoustic(PA)imaging-guided synergistic photothermal therapy(PTT)and photodynamic therapy(PDT)in tumor cells.Owing to unexcepted bromination at the periphery aryl rings,NBDPBr demonstrated an outstanding singlet oxygen quantum yield(ΦΔ)of 66％which was superior to simi-lar brominated photosensitizers previously reported.After encapsulation with amphiphilic polymer F-127,hydrophilic NBDPBr nanoparticles(NPs)were fabricated and exhibited an excellent photothermal conver-sion efficiency(η)of 43.0％under 660 nm photoirradiation.In vivo PA imaging results demonstrated that NBDPBr NPs could specifically accumulate at tumor sites and realized the maximum tumor retention at 7 h post-injection.All the in vitro and in vivo results indicated the significant potence of NBDPBr with unexpected bis-bromination for PA imaging-guided synergetic PDT/PTT.
基金项目
NSF of Jiangsu Province(BK20200092)
NETL
NSTL
万方数据