首页|Aza-BODIPY dye with unexpected bromination and high singlet oxygen quantum yield for photoacoustic imaging-guided synergetic photodynamic/photothermal therapy
Aza-BODIPY dye with unexpected bromination and high singlet oxygen quantum yield for photoacoustic imaging-guided synergetic photodynamic/photothermal therapy
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Introducing heavy halogen atoms into organic small molecules is a practical strategy for efficient sin-glet oxygen(1O2)generation.Generally,bromine or iodine atoms are introduced on the aza-boron-dipyrromethene(aza-BODIPY)core,rather than on the periphery aryl rings for efficient 1O2 generation.Herein,an aza-BODIPY dye NBDPBr with unexpected bromination on the periphery aryl rings was synthe-sized for photoacoustic(PA)imaging-guided synergistic photothermal therapy(PTT)and photodynamic therapy(PDT)in tumor cells.Owing to unexcepted bromination at the periphery aryl rings,NBDPBr demonstrated an outstanding singlet oxygen quantum yield(ΦΔ)of 66％which was superior to simi-lar brominated photosensitizers previously reported.After encapsulation with amphiphilic polymer F-127,hydrophilic NBDPBr nanoparticles(NPs)were fabricated and exhibited an excellent photothermal conver-sion efficiency(η)of 43.0％under 660 nm photoirradiation.In vivo PA imaging results demonstrated that NBDPBr NPs could specifically accumulate at tumor sites and realized the maximum tumor retention at 7 h post-injection.All the in vitro and in vivo results indicated the significant potence of NBDPBr with unexpected bis-bromination for PA imaging-guided synergetic PDT/PTT.
Key Laboratory of Flexible Electronics(KLOFE)& Institute of Advanced Materials(IAM),Nanjing Tech University(NanjingTech),Nanjing 211800,China
Center for Rehabilitation Medicine,Rehabilitation & Sports Medicine Research Institute of Zhejiang Province,Department of Rehabilitation Medicine,Zhejiang Provincial People's Hospital(Affiliated People's Hospital,Hangzhou Medical College),Hangzhou 310014,China
School of Chemistry & Materials Science,Jiangsu Normal University,Xuzhou 221116,China
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