Gas-generating polymersomes-based amplified photoimmunotherapy for abscopal effect and tumor metastasis inhibition

Chenlu Huang ¹Xinyu Yang ¹Qingyu Yu ¹Linhua Zhang ¹Dunwan Zhu¹

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作者信息

1. Tianjin Key Laboratory of Biomedical Materials,Key Laboratory of Biomaterials and Nanotechnology for Cancer Immunotherapy,Institute of Biomedical Engineering,Chinese Academy of Medical Sciences & Peking Union Medical College,Tianjin 300192,China
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Abstract

Due to the heterogeneity of tumors,single phototherapy cannot completely ablate tumors and inhibit tu-mor metastasis.To overcome these,we formulated targeted and multifunctional polymersomes ABC@ICG-IMQ-LHRH(AIRL)that encapsulated Toll-like receptor(TLR)7/8 agonist imiquimod(IMQ)and photosen-sitizer indocyanine green(ICG)in the hydrophobic layer as well as bubble-generator NH4HCO3 in the hydrophilic cavity to inhibit the growth of primary and distant tumors,and prevent tumor metastasis through synergistic photoimmunotherapy.The AIRL polymersomes exhibited uniform and stable size,and high drug encapsulation efficiency,acid/reduction/laser responsiveness,excellent photothermal conver-sion efficiency,effective reactive oxygen species generation,high tumor accumulation.AIRL could be ef-fectively internalized by dendritic cells(DCs),achieve lysosome escape and enhance DCs maturation.The synergistic photoimmunotherapy via AIRL polymersomes remarkably promoted the differentiation and activation of T cells,elevated strong systemic immune response to eradicate primary tumors and inhibit the growth of distant tumors.Simultaneously,the endurable immunological memory prevented tumor metastasis,which provided a promising nanoplatform for the combination therapy of cancer.

Key words

Polymersomes/Phototherapy/Immunotherapy/TLR 7/8 agonist/Gas-generating

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基金项目

National Natural Science Foundation of China(82172090)

National Natural Science Foundation of China(82302390)

National Natural Science Foundation of China(82072059)

CAMS Innovation Fund for Medical Sciences(2021-I2M-1-058)

CAMS Innovation Fund for Medical Sciences(2022-I2M-1-023)

China Postdoctoral Science Foundation(2022M720502)

Tianjin Municipal Natural Science Foundation(22JCQNJC00070)

CAMS Union Young Scholars Support Program(2022051)

Fundamental Research Funds for the Central Universities(2019PT320028)

出版年

2024

中国化学快报(英文版)

中国化学会

中国化学快报(英文版)

CSTPCDCSCD

影响因子：0.771

ISSN：1001-8417

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