首页|Gas-generating polymersomes-based amplified photoimmunotherapy for abscopal effect and tumor metastasis inhibition

Gas-generating polymersomes-based amplified photoimmunotherapy for abscopal effect and tumor metastasis inhibition

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Due to the heterogeneity of tumors,single phototherapy cannot completely ablate tumors and inhibit tu-mor metastasis.To overcome these,we formulated targeted and multifunctional polymersomes ABC@ICG-IMQ-LHRH(AIRL)that encapsulated Toll-like receptor(TLR)7/8 agonist imiquimod(IMQ)and photosen-sitizer indocyanine green(ICG)in the hydrophobic layer as well as bubble-generator NH4HCO3 in the hydrophilic cavity to inhibit the growth of primary and distant tumors,and prevent tumor metastasis through synergistic photoimmunotherapy.The AIRL polymersomes exhibited uniform and stable size,and high drug encapsulation efficiency,acid/reduction/laser responsiveness,excellent photothermal conver-sion efficiency,effective reactive oxygen species generation,high tumor accumulation.AIRL could be ef-fectively internalized by dendritic cells(DCs),achieve lysosome escape and enhance DCs maturation.The synergistic photoimmunotherapy via AIRL polymersomes remarkably promoted the differentiation and activation of T cells,elevated strong systemic immune response to eradicate primary tumors and inhibit the growth of distant tumors.Simultaneously,the endurable immunological memory prevented tumor metastasis,which provided a promising nanoplatform for the combination therapy of cancer.

PolymersomesPhototherapyImmunotherapyTLR 7/8 agonistGas-generating

Chenlu Huang、Xinyu Yang、Qingyu Yu、Linhua Zhang、Dunwan Zhu

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Tianjin Key Laboratory of Biomedical Materials,Key Laboratory of Biomaterials and Nanotechnology for Cancer Immunotherapy,Institute of Biomedical Engineering,Chinese Academy of Medical Sciences & Peking Union Medical College,Tianjin 300192,China

National Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaCAMS Innovation Fund for Medical SciencesCAMS Innovation Fund for Medical SciencesChina Postdoctoral Science FoundationTianjin Municipal Natural Science FoundationCAMS Union Young Scholars Support ProgramFundamental Research Funds for the Central Universities

8217209082302390820720592021-I2M-1-0582022-I2M-1-0232022M72050222JCQNJC0007020220512019PT320028

2024

10.1016/j.cclet.2024.109680

中国化学快报(英文版)
中国化学会

中国化学快报(英文版)

CSTPCD
影响因子：0.771
ISSN：1001-8417
年,卷(期)：2024.35(6)
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