首页|Is reactive oxygen species the only way for cancer inhibition over single atom nanomedicine?Autophagy regulation also works

Is reactive oxygen species the only way for cancer inhibition over single atom nanomedicine?Autophagy regulation also works

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Exploring the therapeutic effect of single atom catalysts beyond reactive oxygen species(ROS)modu-lation would boost the prosperity of nanomedicine in cancer treatment.Autophagy as a vital therapy target offers new options for the control of renal cell carcinoma(RCC)progression.Herein,Fe single atom-decorated graphene oxide(Fe1-GO)nanosheet is developed to be a feasible autophagy inducer in RCC treatment.With the well-dispersed O-Fe1-O active sites,Fe1-GO kills ACHN cells effectively but maintains acceptable cytotoxicity to the normal podocyte and HK2 ones.In-depth analyses ascribe the inhibition of ACHN cells to the upregulated autophagy instead of the commonly known catalytic ROS generation.The in vivo therapeutic effect of Fe1-GO nanomedicine is also validated by the RCC-bearing BALB/c mice model,realizing an 89％reduction of tumor weight and good biosafety.This work provides new insights into the design of autophagy regulators as well as potential therapeutic strategies for RCC treatment.

Fe single atomAutophagyRenal cell carcinomaGraphene oxideCancer therapy

Yuanyi Zhou、Ke Ma、Jinfeng Liu、Zirun Zheng、Bo Hu、Yu Meng、Zhizhong Li、Mingshan Zhu

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Postdoctoral Innovation Practice Base,The First and Fifth Affiliated Hospital of Jinan University,Guangzhou 510632,China

Guangdong Provincial Key Laboratory of Spine and Spinal Cord Reconstruction,The Fifth Affiliated Hospital of Jinan University(Heyuan Shenhe People's Hospital),Heyuan 517465,China

School of Environment,Jinan University,Guangzhou 511443,China

Department of Nephrology,The First Affiliated Hospital of Jinan University,Guangzhou 510632,China

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National Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaChina Postdoctoral Science FoundationNatural Science Foundation of Guangdong,ChinaBasic and Applied Basic Research Foundation of Guangdong Province,ChinaScience and Technology Project of Guangzhou,ChinaScience and Technology Project of Shenzhen,China

5220224082270756820006862021M7014092018A0303135272019A1515010176202102010133JCYJ20190808095615389

2024

10.1016/j.cclet.2023.109056

中国化学快报(英文版)
中国化学会

中国化学快报(英文版)

CSTPCD
影响因子：0.771
ISSN：1001-8417
年,卷(期)：2024.35(6)