Is reactive oxygen species the only way for cancer inhibition over single atom nanomedicine?Autophagy regulation also works

Yuanyi Zhou ¹Ke Ma ²Jinfeng Liu ²Zirun Zheng ²Bo Hu ³Yu Meng ³Zhizhong Li ⁴Mingshan Zhu⁵

扫码查看

作者信息

1. Postdoctoral Innovation Practice Base,The First and Fifth Affiliated Hospital of Jinan University,Guangzhou 510632,China;Guangdong Provincial Key Laboratory of Spine and Spinal Cord Reconstruction,The Fifth Affiliated Hospital of Jinan University(Heyuan Shenhe People's Hospital),Heyuan 517465,China;School of Environment,Jinan University,Guangzhou 511443,China
2. Department of Nephrology,The First Affiliated Hospital of Jinan University,Guangzhou 510632,China
3. Postdoctoral Innovation Practice Base,The First and Fifth Affiliated Hospital of Jinan University,Guangzhou 510632,China;Guangdong Provincial Key Laboratory of Spine and Spinal Cord Reconstruction,The Fifth Affiliated Hospital of Jinan University(Heyuan Shenhe People's Hospital),Heyuan 517465,China;Department of Nephrology,The First Affiliated Hospital of Jinan University,Guangzhou 510632,China
4. Postdoctoral Innovation Practice Base,The First and Fifth Affiliated Hospital of Jinan University,Guangzhou 510632,China;Guangdong Provincial Key Laboratory of Spine and Spinal Cord Reconstruction,The Fifth Affiliated Hospital of Jinan University(Heyuan Shenhe People's Hospital),Heyuan 517465,China
5. Postdoctoral Innovation Practice Base,The First and Fifth Affiliated Hospital of Jinan University,Guangzhou 510632,China;School of Environment,Jinan University,Guangzhou 511443,China
折叠

Abstract

Exploring the therapeutic effect of single atom catalysts beyond reactive oxygen species(ROS)modu-lation would boost the prosperity of nanomedicine in cancer treatment.Autophagy as a vital therapy target offers new options for the control of renal cell carcinoma(RCC)progression.Herein,Fe single atom-decorated graphene oxide(Fe1-GO)nanosheet is developed to be a feasible autophagy inducer in RCC treatment.With the well-dispersed O-Fe1-O active sites,Fe1-GO kills ACHN cells effectively but maintains acceptable cytotoxicity to the normal podocyte and HK2 ones.In-depth analyses ascribe the inhibition of ACHN cells to the upregulated autophagy instead of the commonly known catalytic ROS generation.The in vivo therapeutic effect of Fe1-GO nanomedicine is also validated by the RCC-bearing BALB/c mice model,realizing an 89％reduction of tumor weight and good biosafety.This work provides new insights into the design of autophagy regulators as well as potential therapeutic strategies for RCC treatment.

Key words

Fe single atom/Autophagy/Renal cell carcinoma/Graphene oxide/Cancer therapy

引用本文复制引用

基金项目

National Natural Science Foundation of China(52202240)

National Natural Science Foundation of China(82270756)

National Natural Science Foundation of China(82000686)

China Postdoctoral Science Foundation(2021M701409)

Natural Science Foundation of Guangdong,China(2018A030313527)

Basic and Applied Basic Research Foundation of Guangdong Province,China(2019A1515010176)

Science and Technology Project of Guangzhou,China(202102010133)

Science and Technology Project of Shenzhen,China(JCYJ20190808095615389)

出版年

2024

中国化学快报(英文版)

中国化学会

中国化学快报(英文版)

CSTPCDCSCD

影响因子：0.771

ISSN：1001-8417

参考文献量27

段落导航