Supramolecular phenolic network-engineered C-CeO2 nanofibers for simultaneous determination of isoniazid and hydrazine in biological fluids

Gang Lang ¹Jing Feng ²Bo Feng ³Junlan Hu ¹Zhiling Ran ¹Zhiting Zhou ¹Zhenju Jiang ¹Yunxiang He ⁴Junling Guo⁵

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作者信息

1. School of Science,Xihua University,Chengdu 610039,China
2. School of Science,Xihua University,Chengdu 610039,China;BMI Center for Biomass Materials and Nanointerfaces,College of Biomass Science and Engineering,Sichuan University,Chengdu 610065,China
3. Southwest Computer Co.,Ltd.,Chongqing 400060,China
4. BMI Center for Biomass Materials and Nanointerfaces,College of Biomass Science and Engineering,Sichuan University,Chengdu 610065,China
5. BMI Center for Biomass Materials and Nanointerfaces,College of Biomass Science and Engineering,Sichuan University,Chengdu 610065,China;Bioproducts Institute,Department of Chemical and Biological Engineering,The University of British Columbia,Vancouver V6T 1Z4,Canada;State Key Laboratory of Polymer Materials Engineering,Sichuan University,Chengdu 610065,China;National Engineering Laboratory for Clean Technology of Leather Manufacture Sichuan University,Chengdu 610065,China
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Abstract

Electrochemical sensing provides a powerful technological means for the therapeutic drug monitoring of drug-resistant tuberculosis but requires a functionalized electrode to capture the analytes and catalyze their redox reactions.Herein,we construct a nickel-tannic acid supramolecular network(Ni-TA)on the surface of electrospun-derived C-CeO2 nanofiber for the sensitive and simultaneous detection of isoni-azid(INZ)and hydrazine(HYD).Mechanistic investigations demonstrate that Ni-TA is electronegative and hydrophilic,thus facilitating an efficient mass and electron transfer.Ni-TA/C-CeO2 has higher adsorption rate constants(0.091 g mg-1 h-1 for INZ,and 0.062 g mg-1 h-1 for HYD)than native C-CeO2(0.075 g mg-1 h-1 for INZ,and 0.047 g mg-1 h-1 for HYD).Moreover,Ni-TA/C-CeO2(56 Ω)has lower charge transfer re-sistances than C-CeO2(417 Ω).Ni-TA/C-CeO2 performs low detection limits and wide linearity ranges for INZ(0.012 μmol/L and 0.1-400 μmol/L,respectively)and HYD(0.008 μmol/L and 0.015-1420 μmol/L,respectively),coupled with high selectivity,cycle stability and reproducibility.This research demonstrated the promising applications of Ni-TA/C-CeO2 by analyzing human-collected plasma and urine samples.

Key words

Electrochemical detection/Therapeutic drug monitoring/Isoniazid/Hydrazine/Tuberculosis

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基金项目

Cooperative Education Program of the Ministry of Education,China(202101256027)

Cooperative Education Program of the Ministry of Education,China(202102070134)

National Excellent Young Scientists Found(00308054A1045)

National Key R&D Program of China(2022YFA0912800)

National Natural Science Foundation of China(22178233)

Talents Program of Sichuan Province,Double First Class University Plan of Sichuan University,State Key Laboratory of Polymer Mat(sklpme 2020-03-01)

Sichuan Tianfu Emei Project(2022-EC02-00073-CG)

出版年

2024

中国化学快报(英文版)

中国化学会

中国化学快报(英文版)

CSTPCD

影响因子：0.771

ISSN：1001-8417

参考文献量1

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