首页|Supramolecular phenolic network-engineered C-CeO2 nanofibers for simultaneous determination of isoniazid and hydrazine in biological fluids

Supramolecular phenolic network-engineered C-CeO2 nanofibers for simultaneous determination of isoniazid and hydrazine in biological fluids

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Electrochemical sensing provides a powerful technological means for the therapeutic drug monitoring of drug-resistant tuberculosis but requires a functionalized electrode to capture the analytes and catalyze their redox reactions.Herein,we construct a nickel-tannic acid supramolecular network(Ni-TA)on the surface of electrospun-derived C-CeO2 nanofiber for the sensitive and simultaneous detection of isoni-azid(INZ)and hydrazine(HYD).Mechanistic investigations demonstrate that Ni-TA is electronegative and hydrophilic,thus facilitating an efficient mass and electron transfer.Ni-TA/C-CeO2 has higher adsorption rate constants(0.091 g mg-1 h-1 for INZ,and 0.062 g mg-1 h-1 for HYD)than native C-CeO2(0.075 g mg-1 h-1 for INZ,and 0.047 g mg-1 h-1 for HYD).Moreover,Ni-TA/C-CeO2(56 Ω)has lower charge transfer re-sistances than C-CeO2(417 Ω).Ni-TA/C-CeO2 performs low detection limits and wide linearity ranges for INZ(0.012 μmol/L and 0.1-400 μmol/L,respectively)and HYD(0.008 μmol/L and 0.015-1420 μmol/L,respectively),coupled with high selectivity,cycle stability and reproducibility.This research demonstrated the promising applications of Ni-TA/C-CeO2 by analyzing human-collected plasma and urine samples.

Electrochemical detectionTherapeutic drug monitoringIsoniazidHydrazineTuberculosis

Gang Lang、Jing Feng、Bo Feng、Junlan Hu、Zhiling Ran、Zhiting Zhou、Zhenju Jiang、Yunxiang He、Junling Guo

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School of Science,Xihua University,Chengdu 610039,China

BMI Center for Biomass Materials and Nanointerfaces,College of Biomass Science and Engineering,Sichuan University,Chengdu 610065,China

Southwest Computer Co.,Ltd.,Chongqing 400060,China

Bioproducts Institute,Department of Chemical and Biological Engineering,The University of British Columbia,Vancouver V6T 1Z4,Canada

State Key Laboratory of Polymer Materials Engineering,Sichuan University,Chengdu 610065,China

National Engineering Laboratory for Clean Technology of Leather Manufacture Sichuan University,Chengdu 610065,China

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Cooperative Education Program of the Ministry of Education,ChinaCooperative Education Program of the Ministry of Education,ChinaNational Excellent Young Scientists FoundNational Key R&D Program of ChinaNational Natural Science Foundation of ChinaTalents Program of Sichuan Province,Double First Class University Plan of Sichuan University,State Key Laboratory of Polymer MatSichuan Tianfu Emei Project

20210125602720210207013400308054A10452022YFA091280022178233sklpme 2020-03-012022-EC02-00073-CG

2024

10.1016/j.cclet.2023.109113

中国化学快报(英文版)
中国化学会

中国化学快报(英文版)

CSTPCD
影响因子：0.771
ISSN：1001-8417
年,卷(期)：2024.35(6)
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