Utilizing CO2 for the production of bulky and valuable chemicals presents an attractive solution to ad-dress environmental and fossil energy crises.Among the various approaches,direct carboxylation of alco-hols with CO2 stands out as an eco-friendly process capable of efficiently producing carboxylic acids in a sustainable manner.However,the high dissociation energy of the C-O bond poses a significant challenge in this process.Over the past few decades,several strategies have been developed to activate alcohols and establish efficient catalytic systems for carboxylation with CO2.Nevertheless,the sporadic nature of reported approaches makes it difficult to determine the most effective one.This perspective aims to pro-vide an overview of the current state-of-the-art catalytic protocols for carboxylating alcohols with CO2,encompassing esterification,halogenation,and photocatalysis,while considering their respective advan-tages and limitations.We aim to discern the most promising avenues for future development in this field.The insights presented in this perspective will contribute to the advancement of efficient and sustainable carboxylation methods using CO2,leading to the production of valuable chemicals in future.
CarboxylationCarbon dioxideAlcoholCarboxylic acidTransition metal catalysis
Daheng Wen、Weiwei Fang、Yongmei Liu、Tao Tu
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Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials,Department of Chemistry,Fudan University,Shanghai 200438,China
Jiangsu Co-Innovation Center of Efficient Processing and Utilization of Forest Resources,International Innovation Center for Forest Chemicals and Materials,College of Chemical Engineering,Nanjing Forestry University,Nanjing 210037,China
State Key Laboratory of Organometallic Chemistry,Shanghai Institute of Organic Chemistry,Chinese Academy of Sciences,Shanghai 200032,China
National Natural Science Foundation of ChinaDepartment of Chemistry at Fudan University,and Nanjing Forestry University are gratefully acknowledged
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