首页|Supercritical fluid technology:A game-changer for biomacromolecular nanomedicine preparation and biomedical application

Supercritical fluid technology:A game-changer for biomacromolecular nanomedicine preparation and biomedical application

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Biomacromolecules are attractive in biomedical applications as therapeutic agents and potential drug car-riers due to their natural active components,good biocompatibility,and high targeting.However,their large relative molecular weight,complex structure,susceptibility to degradation,and poor stability limit their usefulness.Nanotechnology can address these issues by improving the therapeutic value,bioavail-ability,permeability,and absorption of biomacromolecules while regulating their retention time in the body.Especially,compelling evidence has been reported that supercritical fluid(SCF)technology has emerged as an alternative that maintains the integrity of biomacromolecules and reduces environmental contamination.In this review,we highlight a set of unique nanosizing strategies based on SCF technol-ogy for biomacromolecular nanomedicine,and extensively discuss their characteristics and mechanisms.In particular,the protein-based,nucleic acid-based,and polysaccharide-based nanomedicine preparations via SCF technology and their biomedical applications are summarized,and the potential for industrial production of biomacromolecular drugs is also considered.We further provide perspectives on the op-portunities and challenges in this excellent field of biomacromolecular drugs nanotechnology.

BiomacromoleculesSupercritical fluid technologyTherapeutic proteinsGene therapyNanomedicine

Yating Zheng、Yulan Huang、Jing Luo、Xuqi Peng、Xiran Gui、Gang Liu、Yang Zhang

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State Key Laboratory of Vaccines for Infectious Diseases,Xiang An Biomedicine Laboratory,National Innovation Platform for Industry-Education Integration in Vaccine Research,State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics,Center for Molecular Imaging and Translational Medicine,School of Public Health,Xiamen University,Xiamen 361102,China

Division of Urology and Department of Surgery,Brigham and Women's Hospital,Harvard Medical School,Boston,MA 02115,United States

Innovation Laboratory for Sciences and Technologies of Energy Materials of Fujian Province(IKKEM),Xiamen 361102,China

Shen Zhen Research Institute of Xiamen University,Shenzhen 518057,China

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Major State Basic Research Development Program of ChinaMajor State Basic Research Development Program of ChinaNational Natural Science Foundation of China(NSFC)National Natural Science Foundation of China(NSFC)National Natural Science Foundation of China(NSFC)National Natural Science Foundation of China(NSFC)Fundamental Research Funds for the Central UniversitiesFundamental Research Funds for the Central UniversitiesScience Foundation of Fujian ProvinceProgram for New Century Excellent Talents in University,ChinaShenzhen Science and Technology ProgramChina Postdoctoral Science Foundation

2023YFB38100002018YFA0107301U22A2033381925019U17052818220233020720190088207202000192020Y4003NCET-13-0502JCYJ202205301432130292023T160383

2024

10.1016/j.cclet.2023.109169

中国化学快报(英文版)
中国化学会

中国化学快报(英文版)

CSTPCD
影响因子：0.771
ISSN：1001-8417
年,卷(期)：2024.35(7)