Supercritical fluid technology:A game-changer for biomacromolecular nanomedicine preparation and biomedical application

Yating Zheng ¹Yulan Huang ¹Jing Luo ²Xuqi Peng ¹Xiran Gui ¹Gang Liu ³Yang Zhang⁴

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作者信息

1. State Key Laboratory of Vaccines for Infectious Diseases,Xiang An Biomedicine Laboratory,National Innovation Platform for Industry-Education Integration in Vaccine Research,State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics,Center for Molecular Imaging and Translational Medicine,School of Public Health,Xiamen University,Xiamen 361102,China
2. Division of Urology and Department of Surgery,Brigham and Women's Hospital,Harvard Medical School,Boston,MA 02115,United States
3. State Key Laboratory of Vaccines for Infectious Diseases,Xiang An Biomedicine Laboratory,National Innovation Platform for Industry-Education Integration in Vaccine Research,State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics,Center for Molecular Imaging and Translational Medicine,School of Public Health,Xiamen University,Xiamen 361102,China;Innovation Laboratory for Sciences and Technologies of Energy Materials of Fujian Province(IKKEM),Xiamen 361102,China
4. State Key Laboratory of Vaccines for Infectious Diseases,Xiang An Biomedicine Laboratory,National Innovation Platform for Industry-Education Integration in Vaccine Research,State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics,Center for Molecular Imaging and Translational Medicine,School of Public Health,Xiamen University,Xiamen 361102,China;Shen Zhen Research Institute of Xiamen University,Shenzhen 518057,China
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Abstract

Biomacromolecules are attractive in biomedical applications as therapeutic agents and potential drug car-riers due to their natural active components,good biocompatibility,and high targeting.However,their large relative molecular weight,complex structure,susceptibility to degradation,and poor stability limit their usefulness.Nanotechnology can address these issues by improving the therapeutic value,bioavail-ability,permeability,and absorption of biomacromolecules while regulating their retention time in the body.Especially,compelling evidence has been reported that supercritical fluid(SCF)technology has emerged as an alternative that maintains the integrity of biomacromolecules and reduces environmental contamination.In this review,we highlight a set of unique nanosizing strategies based on SCF technol-ogy for biomacromolecular nanomedicine,and extensively discuss their characteristics and mechanisms.In particular,the protein-based,nucleic acid-based,and polysaccharide-based nanomedicine preparations via SCF technology and their biomedical applications are summarized,and the potential for industrial production of biomacromolecular drugs is also considered.We further provide perspectives on the op-portunities and challenges in this excellent field of biomacromolecular drugs nanotechnology.

Key words

Biomacromolecules/Supercritical fluid technology/Therapeutic proteins/Gene therapy/Nanomedicine

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基金项目

Major State Basic Research Development Program of China(2023YFB3810000)

Major State Basic Research Development Program of China(2018YFA0107301)

National Natural Science Foundation of China(NSFC)(U22A20333)

National Natural Science Foundation of China(NSFC)(81925019)

National Natural Science Foundation of China(NSFC)(U1705281)

National Natural Science Foundation of China(NSFC)(82202330)

Fundamental Research Funds for the Central Universities(20720190088)

Fundamental Research Funds for the Central Universities(20720200019)

Science Foundation of Fujian Province(2020Y4003)

Program for New Century Excellent Talents in University,China(NCET-13-0502)

Shenzhen Science and Technology Program(JCYJ20220530143213029)

China Postdoctoral Science Foundation(2023T160383)

出版年

2024

中国化学快报(英文版)

中国化学会

中国化学快报(英文版)

CSTPCDCSCD

影响因子：0.771

ISSN：1001-8417

参考文献量136

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