Cobalt-catalyzed reductive alkynylation to construct C(sp)-C(sp3)and C(sp)-C(sp2)bonds

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外文摘要：Transition-metal-catalyzed cross-electrophile coupling has emerged as a reliable method for constructing carbon-carbon bonds.Herein,we report a general method,cobalt-catalyzed reductive alkynylation,to construct C(sp)-C(sp3)and C(sp)-C(sp2)bonds.This presented reaction has a broad substrate scope,enabling the efficient cross-electrophile coupling between alkynyl bromides with alkyl halides and aryl or alkenyl(pseudo)halides.This presented reaction is conducted under mild conditions,tolerating many functional groups,thus suitable for the modification and synthesis of biologically active molecules.

外文关键词：

Cobalt-catalysisCross-electrophile couplingCarbon-carbon bond formationReductive alkynylationAlkyne synthesis

作者：

Lei Wan、Yizhou Tong、Xi Lu、Yao Fu

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作者单位：

Hefei National Research Center for Physical Sciences at the Microscale,iChEM,CAS Key Laboratory of Urban Pollutant Conversion,Anhui Province Key Laboratory of Biomass Clean Energy,University of Science and Technology of China,Hefei 230026,China

Key Laboratory of Precision and Intelligent Chemistry,School of Chemistry and Materials Science,University of Science and Technology of China,Hefei 230026,China

基金：

National Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaYouth Innovation Promotion Association of the Chinese Academy of SciencesNational Science Foundation of Anhui Province

项目编号：

2237127322293011T234100120234762208085J26

出版年：

2024

DOI：

10.1016/j.cclet.2023.109283

中国化学快报(英文版)

中国化学会

中国化学快报(英文版)

CSTPCD

影响因子：0.771

ISSN：1001-8417

年,卷(期)：2024.35(7)