Cobalt-catalyzed reductive alkynylation to construct C(sp)-C(sp3)and C(sp)-C(sp2)bonds

Lei Wan ¹Yizhou Tong ¹Xi Lu ²Yao Fu¹

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作者信息

1. Hefei National Research Center for Physical Sciences at the Microscale,iChEM,CAS Key Laboratory of Urban Pollutant Conversion,Anhui Province Key Laboratory of Biomass Clean Energy,University of Science and Technology of China,Hefei 230026,China
2. Key Laboratory of Precision and Intelligent Chemistry,School of Chemistry and Materials Science,University of Science and Technology of China,Hefei 230026,China
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Abstract

Transition-metal-catalyzed cross-electrophile coupling has emerged as a reliable method for constructing carbon-carbon bonds.Herein,we report a general method,cobalt-catalyzed reductive alkynylation,to construct C(sp)-C(sp3)and C(sp)-C(sp2)bonds.This presented reaction has a broad substrate scope,enabling the efficient cross-electrophile coupling between alkynyl bromides with alkyl halides and aryl or alkenyl(pseudo)halides.This presented reaction is conducted under mild conditions,tolerating many functional groups,thus suitable for the modification and synthesis of biologically active molecules.

Key words

Cobalt-catalysis/Cross-electrophile coupling/Carbon-carbon bond formation/Reductive alkynylation/Alkyne synthesis

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基金项目

National Natural Science Foundation of China(22371273)

National Natural Science Foundation of China(22293011)

National Natural Science Foundation of China(T2341001)

Youth Innovation Promotion Association of the Chinese Academy of Sciences(2023476)

National Science Foundation of Anhui Province(2208085J26)

出版年

2024

中国化学快报(英文版)

中国化学会

中国化学快报(英文版)

CSTPCD

影响因子：0.771

ISSN：1001-8417

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