首页|Highly selective α-C(sp3)-H arylation of alkenyl amides via nickel chain-walking catalysis
Highly selective α-C(sp3)-H arylation of alkenyl amides via nickel chain-walking catalysis
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Herein,we report the migratory hydroarylation of unactivated alkenes with aryl iodides using native and weakly coordinating amide directors under mild conditions.Synergistic coordination of the monoden-tate directing group and the ligand enable the highly regioselective migratory hydroarylation via a chain walking process to form the thermodynamically stable five-membered nickelacyle intermediate.The pro-tocol provides a variety of valuable α-aryl-substituted alkylamine products,and exhibited good functional group tolerance.The modification of bioactive compounds such as fenofibrate and indomethacin further highlights the synthetic value of this protocol.
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