Abstract
Herein,we report the migratory hydroarylation of unactivated alkenes with aryl iodides using native and weakly coordinating amide directors under mild conditions.Synergistic coordination of the monoden-tate directing group and the ligand enable the highly regioselective migratory hydroarylation via a chain walking process to form the thermodynamically stable five-membered nickelacyle intermediate.The pro-tocol provides a variety of valuable α-aryl-substituted alkylamine products,and exhibited good functional group tolerance.The modification of bioactive compounds such as fenofibrate and indomethacin further highlights the synthetic value of this protocol.
基金项目
National Natural Science Foundation of China(21901185)
National Natural Science Foundation of China(22301216)
funds provided by Tianjin Normal University()
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