Base-controlled NHC-Ru-catalyzed transfer hydrogenation and α-methylation/transfer hydrogenation of ketones using methanol

Ming Huang ¹Xiuju Cai ¹Yan Liu ²Zhuofeng Ke³

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作者信息

1. School of pharmacy,School of clinical pharmacy,Guangdong Pharmaceutical University,Guangzhou 510006,China
2. School of Chemical Engineering and Light Industry,Guangdong University of Technology,Guangzhou 510006,China
3. School of Materials Science&Engineering,PCFM Lab,School of Chemistry,Sun Yat-sen University,Guangzhou 510275,China
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Abstract

Herein,we report the NHC-Ru catalyst system that realizes the chemo-selective transformation of ketones with methanol.By simply changing the base,a broad range of structurally diverse ketones,could be se-lectively and efficiently converted to the corresponding β-methylated secondary alcohols or secondary alcohols.Remarkably,this catalytic system was very effective for the synthesis of bio-related molecules and deuterated alcohols,as well as the three-component coupling between methyl ketones,primary al-cohols,and methanol.The reaction mechanism was further revealed by experiment and DFT mechanistic investigations.

Key words

Ru complexes/Methanol/Ketones/β-Methylated secondary alcohols/Transfer hydrogenation

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基金项目

National Natural Science Foundation of China(NSFC)(22002023)

National Natural Science Foundation of China(NSFC)(21973113)

National Natural Science Foundation of China(NSFC)(21977019)

Guangdong Natural Science Funds for Distinguished Young Scholar(2015A030306027)

Tiptop Youth Talents of Guangdong special support program(20153100042090537)

Fundamental Research Funds for the Central Universities()

出版年

2024

中国化学快报(英文版)

中国化学会

中国化学快报(英文版)

CSTPCDCSCD

影响因子：0.771

ISSN：1001-8417

参考文献量24

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