Base-controlled NHC-Ru-catalyzed transfer hydrogenation and α-methylation/transfer hydrogenation of ketones using methanol

扫码查看

原文链接

万方数据

外文摘要：Herein,we report the NHC-Ru catalyst system that realizes the chemo-selective transformation of ketones with methanol.By simply changing the base,a broad range of structurally diverse ketones,could be se-lectively and efficiently converted to the corresponding β-methylated secondary alcohols or secondary alcohols.Remarkably,this catalytic system was very effective for the synthesis of bio-related molecules and deuterated alcohols,as well as the three-component coupling between methyl ketones,primary al-cohols,and methanol.The reaction mechanism was further revealed by experiment and DFT mechanistic investigations.

外文关键词：

Ru complexesMethanolKetonesβ-Methylated secondary alcoholsTransfer hydrogenation

作者：

Ming Huang、Xiuju Cai、Yan Liu、Zhuofeng Ke

展开 >

作者单位：

School of pharmacy,School of clinical pharmacy,Guangdong Pharmaceutical University,Guangzhou 510006,China

School of Chemical Engineering and Light Industry,Guangdong University of Technology,Guangzhou 510006,China

School of Materials Science&Engineering,PCFM Lab,School of Chemistry,Sun Yat-sen University,Guangzhou 510275,China

基金：

National Natural Science Foundation of China(NSFC)National Natural Science Foundation of China(NSFC)National Natural Science Foundation of China(NSFC)Guangdong Natural Science Funds for Distinguished Young ScholarTiptop Youth Talents of Guangdong special support programFundamental Research Funds for the Central Universities

项目编号：

2200202321973113219770192015A03030602720153100042090537

出版年：

2024

DOI：

10.1016/j.cclet.2023.109323

中国化学快报(英文版)

中国化学会

中国化学快报(英文版)

CSTPCD

影响因子：0.771

ISSN：1001-8417

年,卷(期)：2024.35(7)