Visible-light photoredox-catalyzed carboxylation of aryl epoxides with CO2

Tian-Yu Gao ¹Xiao-Yan Mo ¹Shu-Rong Zhang ¹Yuan-Xu Jiang ¹Shu-Ping Luo ²Jian-Heng Ye ¹Da-Gang Yu³

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作者信息

1. Key Laboratory of Green Chemistry&Technology of Ministry of Education,College of Chemistry,Sichuan University,Chengdu 610064,China
2. State Key Laboratory Breeding Base of Green Chemistry-Synthesis Technology,Zhejiang University of Technology,Hangzhou 310014,China
3. Key Laboratory of Green Chemistry&Technology of Ministry of Education,College of Chemistry,Sichuan University,Chengdu 610064,China;State Key Laboratory of Elemento-Organic Chemistry,Nankai University,Tianjin 300071,China
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Abstract

Herein,we report the first visible-light photoredox-catalyzed carboxylation of aryl epoxides with CO2 to synthesize hydroxy acid derivatives.A variety of valuable β-,γ-,δ-,ε-hydroxy acid derivatives are obtained in moderate to high yields under mild conditions.This protocol shows noteworthy functional-group compatibility,high chemo-and regioselectivities under transition-metal-free conditions with an inexpensive organo-dye as photosensitizer.Mechanistic studies indicate that the benzylic carbanion is generated as an intermediate via the sequential single electron transfer(SSET)process.

Key words

Carbon dioxide/Epoxides/Visible-light photoredox catalysis/Hydroxy acid/Sequential single electron transfer

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基金项目

Financial support is provided by the National Natural Science Foundation of China(22225106)

Financial support is provided by the National Natural Science Foundation of China(22301193)

Fundamental Research Funds from Sichuan University(2020SCUNL102)

Fundamental Research Funds for the Central Universities()

出版年

2024

中国化学快报(英文版)

中国化学会

中国化学快报(英文版)

CSTPCDCSCD

影响因子：0.771

ISSN：1001-8417

参考文献量52

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