Abstract
Chemodynamic therapy(CDT)combined with dual phototherapy(photothermal therapy(PTT)and pho-todynamic therapy(PDT))is an efficient way to synergistically improve anti-tumor efficacy.However,the combination of multiple modes often makes the composition of the system more complex,which is not conducive to clinical application.In this study,a dual phototherapy ligand carboxyl-modified Aza-BODIPY(BOD-COOH)and metal active center Cu2+were used to construct multiple-modes metal-photosensitizer nanoparticles(BOD-Cu NPs)via one-step coordination self-assembly for combination ther-apy of CDT/PDT/PTT.In order to improve delivery efficiency,the targeted hydrophilic molecule pyridine-modified glucose derivative(G-Py)was synthesized and coated onto the BOD-Cu NPs to form a glyco-sylated nano metal-photosensitizer BOD-Cu@G by electrostatic interaction.The Cu2+in BOD-Cu@G could not only be used as a coordination node for metal-driven self-assembly but also consume intracellular glutathione(GSH),and then catalyze Fenton-like reaction to generate hydroxyl radical(·OH)for CDT.In vitro and in vivo studies revealed that BOD-Cu@G could achieve excellent anti-tumor efficiency by CDT-enhanced dual phototherapy.
基金项目
National Natural Science Foundation of China(22171230)
Project of Science and Technology of Social Development in Shaanxi Province(2023-YBSF-151)
维普
万方数据