Nano metal-photosensitizer based on Aza-BODIPY-Cu complex for CDT-enhanced dual phototherapy

扫码查看

原文链接

万方数据
维普

外文摘要：Chemodynamic therapy(CDT)combined with dual phototherapy(photothermal therapy(PTT)and pho-todynamic therapy(PDT))is an efficient way to synergistically improve anti-tumor efficacy.However,the combination of multiple modes often makes the composition of the system more complex,which is not conducive to clinical application.In this study,a dual phototherapy ligand carboxyl-modified Aza-BODIPY(BOD-COOH)and metal active center Cu2+were used to construct multiple-modes metal-photosensitizer nanoparticles(BOD-Cu NPs)via one-step coordination self-assembly for combination ther-apy of CDT/PDT/PTT.In order to improve delivery efficiency,the targeted hydrophilic molecule pyridine-modified glucose derivative(G-Py)was synthesized and coated onto the BOD-Cu NPs to form a glyco-sylated nano metal-photosensitizer BOD-Cu@G by electrostatic interaction.The Cu2+in BOD-Cu@G could not only be used as a coordination node for metal-driven self-assembly but also consume intracellular glutathione(GSH),and then catalyze Fenton-like reaction to generate hydroxyl radical(·OH)for CDT.In vitro and in vivo studies revealed that BOD-Cu@G could achieve excellent anti-tumor efficiency by CDT-enhanced dual phototherapy.

外文关键词：

Nano metal-photosensitizerAza-BODIPY-CuCoordination self-assemblyChemodynamic therapyDual phototherapy

作者：

Wenjuan Jin、Zelong Chen、Yi Wang、Jiaxuan Li、Jiahui Li、Yuxin Pei、Zhichao Pei

展开 >

作者单位：

College of Chemistry&Pharmacy,Northwest A&F University,Yangling 712100,China

基金：

National Natural Science Foundation of ChinaProject of Science and Technology of Social Development in Shaanxi Province

项目编号：

221712302023-YBSF-151

出版年：

2024

DOI：

10.1016/j.cclet.2023.109328

中国化学快报(英文版)

中国化学会

中国化学快报(英文版)

CSTPCD

影响因子：0.771

ISSN：1001-8417

年,卷(期)：2024.35(7)