首页|A nitroreductase-responsive nanoprobe with homogeneous composition and high loading for preoperative non-invasive tumor imaging and intraoperative guidance
A nitroreductase-responsive nanoprobe with homogeneous composition and high loading for preoperative non-invasive tumor imaging and intraoperative guidance
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Tumor microenvironment(TME)-activatable probes have been proven to effectively increase signal-to-background ratios(SBRs)and improve the success rate of complete tumor resection.However,many fluo-rescence probes have to be loaded into a nanocarrier for tumor targeted delivery,which consequently en-counters poor drug loading,heterogeneous composition and non-encapsulated drug aggregates occurred during nanoformulation fabrications.Herein,a nitroreductase(NTR)-activated"OFF-ON"near-infrared flu-orescence nanoprobe,named NanoBodipy,was synthesized by the spontaneous self-assembling of NTR-responsive dye-polyethylene glycol(PEG)amphiphilic polymer in water.The NTR-responsive dye acted as the hydrophobic segment in the amphiphilic polymer,yielding a homogeneous composition and a high loading of 12.2 wt% (according to calculation)in the synthesized NanoBodipy.The synthesized NanoBod-ipy can efficiently accumulate in tumors via the enhanced permeability and retention(EPR)effect,en-abling non-invasive tumor-targeted fluorescence imaging and guiding complete tumor resection.Once the synthesized NanoBodipy entered the tumor cells,they dissociated and were activated by overexpressed NTR.With the real-time fluorescence guide of NanoBodipy,complete tumor resection surgery was per-formed successfully.
Institute of Medical Engineering,Department of Biophysics,School of Basic Medical Science,Health Science Center,Xi'an Jiaotong University,Xi'an 710061,China
School of Public Health,Health Science Center,Xi'an Jiaotong University,Xi'an 710061,China
Key Laboratory of Flexible Electronics(KLOFE)&Institute of Advanced Materials(IAM),Nanjing Tech University,Nanjing 211816,China
Department of Breast Surgery,the First Affiliated Hospital of Xi'an Jiaotong University,Xi'an 710061,China
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National Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaNatural Science Foundation of Shaanxi ProvinceOpen Program of NHC Key Laboratory of Nuclear Medicine and Jiangsu Key Laboratory of Molecular Nuclear MedicineHorizontal Project of the First Affiliated Hospital of Xi'an Jiaotong University
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