首页|FRET-based two-photon benzo[a]phenothiazinium photosensitizer for fluorescence imaging-guided photodynamic therapy
FRET-based two-photon benzo[a]phenothiazinium photosensitizer for fluorescence imaging-guided photodynamic therapy
扫码查看
点击上方二维码区域，可以放大扫码查看
原文链接
万方数据
维普
To overcome the conflict between the long-wavelength excitation and high singlet oxygen quantum yield of photosensitizers,we conjugated a two-photon fluorophore,tetrahydroquinoxaline coumarin(TQ),and an efficient photodynamic therapeutic agent,benzo[a]phenothiazinium(NBS-NH2),through a hexamethy-lene linker to build a two-photon photosensitizer,TQ-NBS.In TQ-NBS,TQ served as an energy donor and NBS-NH2 acted as an energy acceptor;and TQ-NBS was a Förster resonance energy transfer(FRET)cas-sette with a 92.8% efficiency.The large two-photon absorption cross-section of TQ allowed photosensitizer TQ-NBS to work in a 900nm two-photon excitation(TPE)mode,which greatly benefited the deep tissue penetration in PDT treatment.Meanwhile,the excellent phototoxicity and near-infrared fluorescence of NBS-NH2 was kept in TQ-NBS under a TPE mode via a FRET process.Photosensitizer TQ-NBS exhibited a high phototoxic efficacy in living cells and tumor-bearing mice.
Yiling Li、Zekun Gao、Xiuxiu Yue、Minhuan Lan、Xiuli Zheng、Benhua Wang、Shuang Zhao、Xiangzhi Song
展开 >
College of Chemistry&Chemical Engineering,Central South University,Changsha 410083,China
Key Laboratory of Photochemical Conversion and Optoelectronic Materials and City U-CAS Joint Laboratory of Functional Materials and Devices,Technical Institute of Physics and Chemistry,Chinese Academy of Sciences,Beijing 100190,China
Department of Dermatology,Xiangya Hospital,Central South University,Changsha 410083,China
National Key Research and Development Program of ChinaNational Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaNational Natural Science Foundation of China
万方数据
维普
