首页|Pyridapeptides F-I,cyclohexapeptides from marine sponge-derived Streptomyces sp.OUCMDZ-4539
Pyridapeptides F-I,cyclohexapeptides from marine sponge-derived Streptomyces sp.OUCMDZ-4539
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Four new cyclohexapeptides,pyridapeptides F-I(1-4),were isolated from the fermentation broth of marine sponge-derived Streptomyces sp.OUCMDZ-4539.The pyridapeptides F-H(1-3)are com-posed of β-hydroxyleucine,alanine,O-methylthreonine,hexahydropyridazine-3-carboxylic acid,5-hydroxytetrahydropyridazine-3-carboxylic acid,and(2S,3R,4E,6E)-2-amino-3-hydroxy-4,6-dienoic acid residues.Pyridapeptide I(4)contains(2S,3R,4E,6E)-2-amino-3-hydroxy-8-methylnona-4,6-dienoic acid residue and a very rare glycose residue,aculose.Their structures were determined based on spectroscopic analysis and chemical methods.Pyridapeptides G-I(2-4)have the 2,3,6-trideoxyhexose units glycosy-lated at the γ-OH-TPDA residue,displayed significant antiproliferative activity against four(PC9,MKN45,HepG2,K562)or two(PC9,MKN45)human cancer cell lines.
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