Pyridapeptides F-I,cyclohexapeptides from marine sponge-derived Streptomyces sp.OUCMDZ-4539

Shuige Zhao ¹Pengcheng Yan ¹Peipei Liu ¹Haishan Liu ²Ning Li ³Peng Fu ⁴Weiming Zhu⁴

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作者信息

1. Key Laboratory of Marine Drugs,Ministry of Education of China,School of Medicine and Pharmacy,Ocean University of China,Qingdao 266003,China
2. School of Biological Science and Technology,University of Jinan,Ji'nan 250022,China
3. Key Laboratory for Biosensors of Shandong Province,Biology Institute,Qilu University of Technology,Ji'nan 250103,China
4. Key Laboratory of Marine Drugs,Ministry of Education of China,School of Medicine and Pharmacy,Ocean University of China,Qingdao 266003,China;Key Laboratory for Marine Drugs and Bioproducts,Laoshan Laboratory,Qingdao 266237,China
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Abstract

Four new cyclohexapeptides,pyridapeptides F-I(1-4),were isolated from the fermentation broth of marine sponge-derived Streptomyces sp.OUCMDZ-4539.The pyridapeptides F-H(1-3)are com-posed of β-hydroxyleucine,alanine,O-methylthreonine,hexahydropyridazine-3-carboxylic acid,5-hydroxytetrahydropyridazine-3-carboxylic acid,and(2S,3R,4E,6E)-2-amino-3-hydroxy-4,6-dienoic acid residues.Pyridapeptide I(4)contains(2S,3R,4E,6E)-2-amino-3-hydroxy-8-methylnona-4,6-dienoic acid residue and a very rare glycose residue,aculose.Their structures were determined based on spectroscopic analysis and chemical methods.Pyridapeptides G-I(2-4)have the 2,3,6-trideoxyhexose units glycosy-lated at the γ-OH-TPDA residue,displayed significant antiproliferative activity against four(PC9,MKN45,HepG2,K562)or two(PC9,MKN45)human cancer cell lines.

Key words

Marine microorganism/Streptomyces/Cyclopeptide glycosides/Pyridapeptides/Antiproliferative activity

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基金项目

National Natural Science Foundation of China(U1906213)

National Key Research and Development Program of China(2022YFC2804100)

出版年

2024

中国化学快报(英文版)

中国化学会

中国化学快报(英文版)

CSTPCDCSCD

影响因子：0.771

ISSN：1001-8417

参考文献量15

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