Active-transporting of charge-reversal Cu(Ⅱ)-doped mesoporous silica nanoagents for antitumor chemo/chemodynamic therapy

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外文摘要：Fe-based Fenton agents can generate highly reactive and toxic hydroxyl radicals(·OH)in the tumor mi-croenvironment(TME)for chemodynamic therapy(CDT)with high specificity.However,the low pH en-vironment and insufficient endogenous hydrogen peroxide(H2O2)of the highly efficient Fenton reaction limits its practical application in clinic.Here,a Cu(Ⅱ)-doped mesoporous silica nanoagent(Cu-MSN)with excellent dispersity was successfully developed.After loaded with doxorubicin(DOX)and ascorbate(AA),Cu-MSN@DA was coated with active targeting ligand folic acid(FA),dimethyl maleic an-hydride(DMMA)and carboxymethyl chitosan(CMC)to obtain an active transporting nanoagent(FCDC@Cu-MSN@DA)with tunable charge-reversal property,which is more adaptable to the pH value of TME than Fe-based Fenton agents,and can self-supply exogenous H2O2 by ascorbate to produce more toxic·OH to trigger the apop-tosis of cancer cells.Meanwhile,the high level of glutathione(GSH)in TME can reduce Cu(Ⅱ)to Cu(Ⅰ)by Fenton-like reaction,increasing the generation rate of·OH and relieving tumor antioxidant ability.The supply of exogenous H2O2 significantly enhanced the synergistic effect of CDT by oxidative damage.To-gether with DOX-induced cell apoptosis,this novel nanoagent FCDC@Cu-MSN@DA can achieve maximum therapeutic efficacy,creating a new model of safe and effective tumor treatment with high specificity.

外文关键词：

Cu(Ⅱ)-dopedAscorbateHydrogen peroxideCharge-reversalOxidative damage

作者：

Zhaomin Tang、Qian He、Jianren Zhou、Shuang Yan、Li Jiang、Yudong Wanga、Chenxing Yao、Huangzhao Wei、Keda Yang、Jiajia Wang

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作者单位：

School of New Energy and Materials,Southwest Petroleum University,Chengdu 610500,China

Dalian Institute of Chemical Physics,Chinese Academy of Sciences,Dalian 116023,China

Shulan International Medical College,Zhejiang Shuren University,Hangzhou 310015,China

Department of Laboratory Medicine,Sichuan Provincial People's Hospital,University of Electronic Science and Technology of China,Chengdu 610072,China

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基金：

National Key Research and Development Program of ChinaNational Natural Science Foundation of China Youth FundNational Natural Science Foundation of China Youth FundNatural Science Foundation of Sichuan ProvinceFoundation of Sichuan Engineering Technology Research Center of Basalt Fiber Composites Development and Application of South

项目编号：

2019YFA0705803518031748210247024NSFSC47982022SCXWYXWFC002

出版年：

2024

DOI：

10.1016/j.cclet.2024.109742

中国化学快报(英文版)

中国化学会

中国化学快报(英文版)

CSTPCD

影响因子：0.771

ISSN：1001-8417

年,卷(期)：2024.35(7)