中国化学快报(英文版)2024,Vol.35Issue(8) :93-100.DOI:10.1016/j.cclet.2023.109276

Exploring the functional roles of small-molecule metabolites in disease research:Recent advancements in metabolomics

Aolei Tan Xiaoxiao Ma
中国化学快报(英文版)2024,Vol.35Issue(8) :93-100.DOI:10.1016/j.cclet.2023.109276

Exploring the functional roles of small-molecule metabolites in disease research:Recent advancements in metabolomics

Aolei Tan 1Xiaoxiao Ma1
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作者信息

  • 1. Department of Precision Instrument,Tsinghua University,Beijing 100084,China
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Abstract

Metabolism encompasses a series of intricate biochemical processes that are vital for the sustenance of life in organisms.Metabolomics,an essential scientific discipline,is a field of study within the broader domain of systems biology that focuses on the comprehensive analysis of small molecules,known as metabolites including lipids,coenzymes,etc.,which are synthesized during metabolism.With the contin-uous development of metabolomics,the multiple biological functions of metabolites are constantly being discovered,encompassing signal transduction and enzyme stimulation,while concurrently exhibiting as-sociations with afflictions like cancer and diabetes.The comprehension of metabolite functionalities and their intricate interplay with disease conditions assumes paramount importance in both disease-focused research endeavors and the development of diagnostic tools.This scholarly exposition undertakes an ex-tensive review of recent advancements in the investigation of functional roles assumed by metabolites,with specific emphasis on metabolites in lipid synthesis,glucose metabolism and exogenous metabolites.

Key words

Metabolites/Small molecules/Biological functions/Physiological processes/Diseases

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出版年

2024
中国化学快报(英文版)
中国化学会

中国化学快报(英文版)

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影响因子:0.771
ISSN:1001-8417
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