Microfluidic-based isolation of circulating tumor cells with high-efficiency and high-purity

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外文摘要：The isolation of circulating tumor cells(CTCs)from complex biological samples is of paramount signifi-cance for advancing cancer diagnosis,prognosis,and treatment.However,the low concentration of CTCs and nonspecific adhesion of white blood cells(WBCs)present challenges that hinder the efficiency and purity of captured CTCs.Microfluidic-based strategies utilize precise fluid control at the micron level to incorporate specific micro/nanostructures or recognition molecules,enabling effective CTCs separation.Moreover,by employing surface modification designs that exhibit exceptional anti-adhesion properties against WBCs,the purity of isolated CTCs can be further enhanced.This review offers an in-depth explo-ration of recent advancements,challenges,and opportunities associated with microfluidic-based CTCs iso-lation from biological samples.Firstly,we will comprehensively introduce the microfluidic-based strate-gies for achieving high-efficiency CTCs isolation,which includes the morphological design of microchan-nels for physical force-based CTCs isolation and the specific modification of microchannel surfaces for affinity-based CTCs isolation.Subsequently,a review of recent research advances in microfluidic-based high-purity CTCs isolation is presented,focusing on strategies that decrease the nonspecific adhesion of WBCs through surface micro-/nanostructure construction or chemical and biological modification.Finally,we will summarize the article by providing the prospective opportunities and challenges for the future development of microfluidic-based CTCs isolation.

外文关键词：

MicrofluidicsIsolationCirculating tumor cellsHigh-efficiencyHigh-purity

作者：

Feng Wu、Xuemin Kong、Yixuan Liu、Shuli Wang、Zhong Chen、Xu Hou

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作者单位：

College of Physics and New Energy,Xuzhou University of Technology,Xuzhou 221018,China

Fujian Engineering Research Center for Solid-State Lighting,Department of Electronic Science,School of Electronic Science and Engineering,Xiamen University,Xiamen,361005,China

Fujian Engineering Research Center for Solid-State Lighting,Department of Electronic Science,School of Electronic Science and Engineering,Xiamen University,Xiamen 361005,China

Innovation Laboratory for Sciences and Technologies of Energy Materials of Fujian Province(IKKEM),Xiamen 361102,China

State Key Laboratory of Physical Chemistry of Solid Surfaces,College of Chemistry and Chemical Engineering,Xiamen University,Xiamen 361005,China

College of Physical Science and Technology,Xiamen University,Xiamen 361005,China

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出版年：

2024

DOI：

10.1016/j.cclet.2024.109754

中国化学快报(英文版)

中国化学会

中国化学快报(英文版)

CSTPCD

影响因子：0.771

ISSN：1001-8417

年,卷(期)：2024.35(8)