首页|Recent advances in photochemistry for positron emission tomography imaging
Recent advances in photochemistry for positron emission tomography imaging
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As a powerful noninvasive imaging technology,positron emission tomography(PET)has been playing an important role in disease theranostics and drug discovery.The successful application of PET relies on not only the biological properties of PET tracers but also the availability of facile and efficient radiochemical reactions to enable practical production and widespread use of PET tracers.Most recently,photochemistry is emerging as a novel,mild and efficient approach to generating PET agents.In this review,we focus on the recent advances in newly developed photocatalytic radiochemical reactions,innovation on automated photochemical radiosynthesis modules,as well as implementation in late-stage radiolabeling and radio-pharmaceutical synthesis for PET imaging.We believe that this review will inspire the development of more promising radiolabeling protocols for the preparation of clinically useful PET agents.
Jiangsu Co-Innovation Center of Efficient Processing and Utilization of Forest Resources,Jiangsu Provincial Key Lab for the Chemistry and Utilization of Agro-Forest Biomass,Jiangsu Key Lab of Biomass-Based Green Fuels and Chemicals,International Innovation Center for Forest Chemicals and Materials,College of Chemical Engineering,Nanjing Forestry University,Nanjing 210037,China
Department of Radiology and Imaging Sciences,Emory University,Atlanta,GA 30322,United States
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