HSA shrinkage optimizes the photostability of embedded dyes fundamentally to amplify their efficiency as photothermal materials

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外文摘要：Focused on the performance promotion of organic small molecular dyes based photothermal agents via non-chemical modification,we found that heat-assisted binding of human serum albumin(HSA)to the dye causes shrinkage of the protein and encapsulate the dye to form nanoparticles.This revolutionizes the photostability of small molecule dyes which further improves their photothermal conversion effi-ciency and tumor ablation performance as photothermal agents significantly.In this work,the obtained photothermal agent named HSA-P2-T could accumulate in tumor and induce 22 ℃ enhancement of the tumor in xenograft models upon ultra-low dose(0.1 W/cm2)laser irradiation,which,as far as we know,is the lowest laser dose used in vivo photothermal therapy.Utilizing HSA-P2-T,we realized tumor ablation upon twice intravenous injections of the nanoparticles and four photothermal treatments.

外文关键词：

Photothermal therapyCyanine dyesPhotostabilityAlbuminEncapsulation

作者：

Yongkang Yue、Zhou Xu、Kaiqing Ma、Fangjun Huo、Xuemei Qin、Kuanshou Zhang、Caixia Yin

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作者单位：

Department Key Laboratory of Chemical Biology and Molecular Engineering of Ministry of Education,Institute of Molecular Science,Shanxi University,Taiyuan 030006,China

Department Modern Research Center for Traditional Chinese Medicine,Shanxi University,Taiyuan 030006,China

Research Institute of Applied Chemistry,Shanxi University,Taiyuan 030006,China

State Key Laboratory of Quantum Optics and Quantum Optics Devices,Institute of Opto-Electronics,Shanxi University,Taiyuan 030006,China

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出版年：

2024

DOI：

10.1016/j.cclet.2023.109223

中国化学快报(英文版)

中国化学会

中国化学快报(英文版)

CSTPCD

影响因子：0.771

ISSN：1001-8417

年,卷(期)：2024.35(8)