A biocompatible Horner-Wadsworth-Emmons(HWE)reaction triggered by a bioorthogonal proximity-induced platform

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外文摘要：Here,we present a novel bioorthogonal platform that enables precise positioning of attached moieties in close proximity,thereby facilitating the discovery and optimization of biocompatible reactions.Using this platform,we achieve a Horner-Wadsworth-Emmons(HWE)reaction under physiological conditions,generating a fluorophore in situ with a yield of up to 93％.This proximity platform should facilitate the discovery of various types of biocompatible reactions,making it a versatile tool for biomedical applica-tions.

外文关键词：

Biocompatible reactionsHorner-Wadsworth-Emmons reactionBioorthogonal reactionsTetrazinesProximity effects

作者：

Yayue Wang、Haojie Yang、Jie Li、Qiao Kong、Siming Zhou、Hongbao Sun、Lili Pan、Qiyong Gong、Ping Feng、Haoxing Wu

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作者单位：

Department of Radiology and Huaxi MR Research Center(HMRRC),Functional and Molecular Imaging Key Laboratory of Sichuan Province,Frontiers Science Center for Disease Related Molecular Network,West China Hospital,Sichuan University,Chengdu 610041,China

Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry and Sichuan Province,Sichuan University,Chengdu 610041,China

Department of Nuclear Medicine,Laboratory of Clinical Nuclear Medicine,West China Hospital,Sichuan University,Chengdu 610041,China

Reseacrch Unit of Psychoradiology,Chinese Academy of Medical Sciences,Chengdu 610041,China

Department of Pharmacy,West China Hospital,Sichuan University,Chengdu 610041,China

Clinical Trial Center and National Medical Products Administration Key Laboratory for Clinical Research and Evaluation of Innovative Drugs,West China Hospital,Sichuan University,Chengdu 610041,China

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出版年：

2024

DOI：

10.1016/j.cclet.2023.109226

中国化学快报(英文版)

中国化学会

中国化学快报(英文版)

CSTPCD

影响因子：0.771

ISSN：1001-8417

年,卷(期)：2024.35(8)