首页|Active molecule-based theranostic agents for tumor vasculature normalization and antitumor efficacy
Active molecule-based theranostic agents for tumor vasculature normalization and antitumor efficacy
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Tumor vascular normalization has emerged as a promising strategy for synergistic therapy recently.Based on the strategy of"fluorescence turn on-controllable release",a novel bifunctional candidate was con-structed based on previous developed vascular normalization inducer QDAU5,which could self-assemble to form functional enzyme infrared QDAU5 nanoparticles(FEIRQ NPs).Subsequently,biological evaluation demonstrated that the FEIRQ NPs could induce ferroptosis,endoplasmic reticulum stress,and antigen pre-conditioning and maturation of dendritic cells and CD8+T cells,leading to excellent antitumor efficacy in the absence of cytotoxic drugs.Additionally,FEIRQ NPs show high fluorescence intensity upon expo-sure to the β-galactosidase(β-Gal)enzyme expressed in ovarian cancer,enabling real-time monitoring of therapeutic effects.Overall,our findings suggest a prospering strategy to early diagnosis and efficient therapy for ovarian cancer without cytotoxicity.
Tumor vasculature normalizationDiagnosis and treatmentCytotoxicityDepleting glutathioneFerroptosisImmune activation
Jin Wang、Xiaoyan Pan、Junyu Zhang、Qingqing Zhang、Yanchen Li、Weiwei Guo、Jie Zhang
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School of Pharmacy,Health Science Center,Xi'an Jiaotong University,Xi'an 710061,China
Center of Advanced Pharmaceuticals and Biomaterials,State Key Laboratory of Natural Medicine,China Pharmaceutical University,Nanjing 210009,China
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