An unexpected stereochemical effect of thio-substituted Asp in native chemical ligation

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外文摘要：This study presents an unexpected finding that the cis isomer of β-thio-Asp exhibits higher ligation ac-tivity than the trans isomer.This discovery sheds light on the intricate nature of native chemical ligation and highlights the importance of factors beyond the steric effects of the side chain in modulating ligation activity.

外文关键词：

Native chemical ligationStereochemistryLigation activityβ-Thio-AspIntramolecular hydrogen bond

作者：

Min Fu、Pan He、Sen Zhou、Wenqiang Liu、Bo Ma、Shiying Shang、Yaohao Li、Ruihan Wang、Zhongping Tan

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作者单位：

State Key Laboratory of Bioactive Sub stance and Function of Natural Medicines,Institute of Materia Medica,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100050,China

Center of Pharmaceutical Technology,School of Pharmaceutical Sciences,Tsinghua University,Beijing 100084,China

State Key Laboratory of Bioactive Substance and Function of Natural Medicines,Institute of Materia Medica,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100050,China

Chemical Engineering College,Hebei Normal University of Science and Technology,Qinhuangdao 066600,China

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出版年：

2024

DOI：

10.1016/j.cclet.2023.109434

中国化学快报(英文版)

中国化学会

中国化学快报(英文版)

CSTPCD

影响因子：0.771

ISSN：1001-8417

年,卷(期)：2024.35(8)