Cocktail effect of ionic patch driven by triboelectric nanogenerator for diabetic wound healing

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外文摘要：There is increasing evidence shows that either electrical stimulation(ES)or metal ion is an effective way to accelerate ulcerative wound healing.However,less attention is paid to investigating the synergistic effect between them.Herein,we explore the combined effects of ES and multiple metal ions on dia-betic wound healing assisted by a triboelectric nanogenerator(TENG).Firstly,the novel Eggshell@CuFe2O4 nanocomposites(NCs)are prepared,which show unique structure and intrinsic antimicrobial properties.Subsequently,the as-prepared nanocomposites are embedded in oxidized starch hydrogel to form a mul-tifunctional composite gel,which is further assembled into a wearable ionic triboelectric nanogenerator(iTENG)patch with polydimethylsiloxane(PDMS).It can convert the mechanical energy produced by a human body motion to electric energy and mediate the sequential release of metal ions(Fe2+/Ca2+/Cu2+),thereby resulting in the"cocktail effect"on impaired tissue.Under their effects,a satisfying healing re-sult in diabetic mouse is identified,which can effectively accelerate wound healing process by relieving inflammation,promoting angiogenesis and collagen deposition.The work puts forward the cocktail effect of electric simulation coupled with the multiple metal ions,and opens up a new perspective in designing iTENG patch towards repair of hard-to-heal wounds.

外文关键词：

iTENGCocktail effectCuFe2O4EggshellDiabetic wound

作者：

Yixia Zhang、Caili Xue、Yunpeng Zhang、Qi Zhang、Kai Zhang、Yulin Liu、Zhaohui Shan、Wu Qiu、Gang Chen、Na Li、Hulin Zhang、Jiang Zhao、Da-Peng Yang

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作者单位：

College of Biomedical Engineering,Taiyuan University of Technology,Taiyuan 030024,China

College of Electronic Information and Optical Engineering,Taiyuan University of Technology,Taiyuan 030024,China

Shanxi-Zheda Institute of Advanced Materials and Chemical Engineering,Taiyuan 030024,China

School of Rehabilitation Science and Engineering,University of Health and Rehabilitation Sciences,Qingdao 266024,China

College of Integrated Circuit Science and Engineering,Nanjing University of Posts and Telecommunications,Nanjing 210023,China

School of Materials and Chemical Engineering,Quanzhou Normal University,Quanzhou 362000,China

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出版年：

2024

DOI：

10.1016/j.cclet.2023.109196

中国化学快报(英文版)

中国化学会

中国化学快报(英文版)

CSTPCD

影响因子：0.771

ISSN：1001-8417

年,卷(期)：2024.35(8)