Chlorogenic acid supported strontium polyphenol networks ensemble microneedle patch to promote diabetic wound healing

Peizhe Li ¹Qiaoling Liu ²Mengyu Pei ³Yuci Gan ¹Yan Gong ⁴Chuchen Gong ¹Pei Wang ⁴Mingsong Wang ⁴Xiansong Wang ⁴Da-Peng Yang ⁵Bo Liang ²Guangyu Ji⁴

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作者信息

1. Research Institute of Plastic Surgery,Weifang Medical University,Weifang 261000,China
2. The Second Affiliated Hospital of Fujian Medical University,Quanzhou 362000,China
3. The Third Affiliated Hospital of Xinxiang Medical University,Institutes of Health Central Plain,Clinical Medical Center of Tissue Engineering and Regeneration,Xinxiang Medical University,Xinxiang 453003,China
4. Department of Thoracic Surgery,Shanghai Key Laboratory of Tissue Engineering,Shanghai Ninth People's Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai 200011,China
5. The Second Affiliated Hospital of Fujian Medical University,Quanzhou 362000,China;School of Rehabilitation Science and Engineering,University of Health and Rehabilitation Sciences,Qingdao 266024,China
折叠

Abstract

Delayed or non-healing of diabetic wounds is a significant complication,often attributed to high glucose-induced M1 macrophage accumulation,impaired angiogenesis,and reactive oxygen species(ROS)buildup.Addressing this,we introduced a strontium polyphenol network microneedle patch(SrC-MPNs@MN-PP)for percutaneous drug delivery.This patch,formulated with polymer poly(γ-glutamic acid)(γ-PGA)and epsilon-poly-L-lysine(ε-PLL),incorporates strontium polyphenol networks(SrC-MPNs).The release of chlorogenic acid(CGA)from SrC-MPNs not only neutralizes ROS,but strontium ions also foster angiogen-esis.Consequently,SrC-MPNs@MN-PP can ameliorate the diabetic wound microenvironment and expedite healing.

Key words

Chlorogenic acid/Strontium/Microneedle patch/Strontium polyphenol network/Exudate absorption/Diabetic wound healing

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出版年

2024

中国化学快报(英文版)

中国化学会

中国化学快报(英文版)

CSTPCDCSCD

影响因子：0.771

ISSN：1001-8417

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