Chlorogenic acid supported strontium polyphenol networks ensemble microneedle patch to promote diabetic wound healing

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外文摘要：Delayed or non-healing of diabetic wounds is a significant complication,often attributed to high glucose-induced M1 macrophage accumulation,impaired angiogenesis,and reactive oxygen species(ROS)buildup.Addressing this,we introduced a strontium polyphenol network microneedle patch(SrC-MPNs@MN-PP)for percutaneous drug delivery.This patch,formulated with polymer poly(γ-glutamic acid)(γ-PGA)and epsilon-poly-L-lysine(ε-PLL),incorporates strontium polyphenol networks(SrC-MPNs).The release of chlorogenic acid(CGA)from SrC-MPNs not only neutralizes ROS,but strontium ions also foster angiogen-esis.Consequently,SrC-MPNs@MN-PP can ameliorate the diabetic wound microenvironment and expedite healing.

外文关键词：

Chlorogenic acidStrontiumMicroneedle patchStrontium polyphenol networkExudate absorptionDiabetic wound healing

作者：

Peizhe Li、Qiaoling Liu、Mengyu Pei、Yuci Gan、Yan Gong、Chuchen Gong、Pei Wang、Mingsong Wang、Xiansong Wang、Da-Peng Yang、Bo Liang、Guangyu Ji

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作者单位：

Research Institute of Plastic Surgery,Weifang Medical University,Weifang 261000,China

The Second Affiliated Hospital of Fujian Medical University,Quanzhou 362000,China

The Third Affiliated Hospital of Xinxiang Medical University,Institutes of Health Central Plain,Clinical Medical Center of Tissue Engineering and Regeneration,Xinxiang Medical University,Xinxiang 453003,China

Department of Thoracic Surgery,Shanghai Key Laboratory of Tissue Engineering,Shanghai Ninth People's Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai 200011,China

School of Rehabilitation Science and Engineering,University of Health and Rehabilitation Sciences,Qingdao 266024,China

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出版年：

2024

DOI：

10.1016/j.cclet.2023.109457

中国化学快报(英文版)

中国化学会

中国化学快报(英文版)

CSTPCD

影响因子：0.771

ISSN：1001-8417

年,卷(期)：2024.35(8)