首页|Electricity-driven enantioselective cross-dehydrogenative coupling of two C(sp3)-H bonds enabled by organocatalysis
Electricity-driven enantioselective cross-dehydrogenative coupling of two C(sp3)-H bonds enabled by organocatalysis
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An efficient and scalable electrochemical asymmetric protocol with metal-free catalysts and even with-out additional oxidants for the cross-dehydrogenative coupling reaction(CDC)of two C(sp3)-H bonds is reported.A series of aldehydes including natural products and various substrates containing C(sp3)-H bonds including xanthenes,acridines,cycloheptatrienes and even diarylmethane have been shown to un-dergo asymmetric CDC to afford a series of carbon-carbon bond coupling products with up to 94％yield and 98％ee.Mechanistic studies such as radical clock experiment suggest that the reaction proceeds via nucleophilic attack by enamine under electrochemical conditions.
AminocatalysisElectrochemistryAsymmetric catalysisCDC of C(sp3)-H bonds
Yuemin Chen、Yunqi Wu、Guoao Wang、Feihu Cui、Haitao Tang、Yingming Pan
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State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources,School of Chemistry and Pharmaceutical Sciences of Guangxi Normal University,Guilin 541004,China
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