Abstract
An efficient and scalable electrochemical asymmetric protocol with metal-free catalysts and even with-out additional oxidants for the cross-dehydrogenative coupling reaction(CDC)of two C(sp3)-H bonds is reported.A series of aldehydes including natural products and various substrates containing C(sp3)-H bonds including xanthenes,acridines,cycloheptatrienes and even diarylmethane have been shown to un-dergo asymmetric CDC to afford a series of carbon-carbon bond coupling products with up to 94％yield and 98％ee.Mechanistic studies such as radical clock experiment suggest that the reaction proceeds via nucleophilic attack by enamine under electrochemical conditions.
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