Niduenes A-F,six functionalized sesterterpenoids with a pentacyclic 5/5/5/5/6 skeleton from endophytic fungus Aspergillus nidulans

Aimin Fu Chunmei Chen Qin Li Nanjin Ding Jiaxin Dong Yu Chen Mengsha Wei Weiguang Sun Hucheng Zhu Yonghui Zhang

中国化学快报(英文版)2024，Vol.35Issue(9) ：202-205.DOI:10.1016/j.cclet.2023.109100

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Niduenes A-F,six functionalized sesterterpenoids with a pentacyclic 5/5/5/5/6 skeleton from endophytic fungus Aspergillus nidulans

Aimin Fu ¹Chunmei Chen ¹Qin Li ¹Nanjin Ding ¹Jiaxin Dong ¹Yu Chen ¹Mengsha Wei ¹Weiguang Sun ¹Hucheng Zhu ¹Yonghui Zhang¹

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作者信息

1. Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation,School of Pharmacy,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,China
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Abstract

Niduenes A-F(1-6),six novel sesterterpenoids with unprecedented 5/5/5/5/6 pentacyclic ring skeleton were isolated from endophytic fungus Aspergillus nidulans.Compounds 1 and 2 represent the first ex-amples of aromatic pentacyclic sesterterpenoids.Their structures and configurations were elucidated by spectroscopic data and single-crystal X-ray diffraction analyses.Compound 4 demonstrated potent re-sensitization of SW620/AD300 cells to paclitaxel(PTX).Rhodamine 123 accumulation assay and docking analysis further support that 4 inhibitory the efflux function of P-glycoprotein(P-gp).

Key words

Aspergillus nidulans/Sesterterpenoids/Aromatic sesterterpenoids/Structure elucidation/Single-crystal X-ray diffraction/Biosynthetic pathways

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出版年

2024

中国化学快报(英文版)

中国化学会

中国化学快报(英文版)

CSTPCDCSCD

影响因子：0.771

ISSN：1001-8417

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