Abstract
Two novel fungal metabolites,asperochones A and B,were obtained from an Aspergillus sp.Their struc-tures were determined by 1D/2D nuclear magnetic resonance(NMR)spectroscopy,high resolution elec-trospray ionization mass spectroscopy(HRESIMS),and single-crystal X-ray diffraction analysis.Aspero-chone A possesses an intriguing skeleton bearing 5/6/6/6/7/5/5/5 octacyclic ring system,and asperochone B also exhibits an unusual carbon skeleton with five stereochiral centers.Their structures were proposed as heterotrimeric and heterodimeric products of aromatic polyketides.In addition,asperochone A ex-hibited a potential anti-tuberculosis effect since it showed a moderate potency against Mycobacterium smegmatis.
维普
万方数据