首页|Asperochones A and B,two antimicrobial aromatic polyketides from the endophytic fungus Aspergillus sp.MMC-2
Asperochones A and B,two antimicrobial aromatic polyketides from the endophytic fungus Aspergillus sp.MMC-2
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Two novel fungal metabolites,asperochones A and B,were obtained from an Aspergillus sp.Their struc-tures were determined by 1D/2D nuclear magnetic resonance(NMR)spectroscopy,high resolution elec-trospray ionization mass spectroscopy(HRESIMS),and single-crystal X-ray diffraction analysis.Aspero-chone A possesses an intriguing skeleton bearing 5/6/6/6/7/5/5/5 octacyclic ring system,and asperochone B also exhibits an unusual carbon skeleton with five stereochiral centers.Their structures were proposed as heterotrimeric and heterodimeric products of aromatic polyketides.In addition,asperochone A ex-hibited a potential anti-tuberculosis effect since it showed a moderate potency against Mycobacterium smegmatis.
Aspergillus sp.Asperochones A and BAromatic polyketidesHeterotrimeric compoundAnti-tuberculosis effectAntifibrotic activity
Hong Zhang、Cui-Ping Li、Li-Li Wang、Zhuo-Da Zhou、Wen-Sen Li、Ling-Yi Kong、Ming-Hua Yang
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Jiangsu Key Laboratory of Bioactive Natural Product Research and State Key Laboratory of Natural Medicines,China Pharmaceutical University,Nanjing 210009,China
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