Palladium-free chemoselective probe for in vivo fluorescence imaging of carbon monoxide

Gongcheng Ma ¹Qihang Ding ²Yuding Zhang ³Yue Wang ⁴Jingjing Xiang ⁵Mingle Li ⁶Qi Zhao ⁷Saipeng Huang ⁸Ping Gong ¹Jong Seung Kim²

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作者信息

1. Guangdong Key Laboratory of Nanomedicine,Shenzhen Engineering Laboratory of Nanomedicine and Nanoformulations,CAS-HK Joint Lab for Biomaterials,Research Laboratory for Biomedical Optics and Molecular Imaging,Shenzhen Key Laboratory for Molecular Imaging,CAS Key Lab for Health Informatics,Shenzhen Institutes of Advanced Technology,Chinese Academy of Sciences,Shenzhen 518055,China;University of Chinese Academy of Sciences,Beijing 100049,China
2. Department of Chemistry,Korea University,Seoul 02841,South Korea
3. Guangdong Key Laboratory of Nanomedicine,Shenzhen Engineering Laboratory of Nanomedicine and Nanoformulations,CAS-HK Joint Lab for Biomaterials,Research Laboratory for Biomedical Optics and Molecular Imaging,Shenzhen Key Laboratory for Molecular Imaging,CAS Key Lab for Health Informatics,Shenzhen Institutes of Advanced Technology,Chinese Academy of Sciences,Shenzhen 518055,China;School of Chemical Engineering,Northwest University,Xi'an 710069,China
4. Guangdong Key Laboratory of Nanomedicine,Shenzhen Engineering Laboratory of Nanomedicine and Nanoformulations,CAS-HK Joint Lab for Biomaterials,Research Laboratory for Biomedical Optics and Molecular Imaging,Shenzhen Key Laboratory for Molecular Imaging,CAS Key Lab for Health Informatics,Shenzhen Institutes of Advanced Technology,Chinese Academy of Sciences,Shenzhen 518055,China;Cancer Center,Institute of Translational Medicine,Faculty of Health Sciences,University of Macau,Macau 999078,China
5. Guangdong Key Laboratory of Nanomedicine,Shenzhen Engineering Laboratory of Nanomedicine and Nanoformulations,CAS-HK Joint Lab for Biomaterials,Research Laboratory for Biomedical Optics and Molecular Imaging,Shenzhen Key Laboratory for Molecular Imaging,CAS Key Lab for Health Informatics,Shenzhen Institutes of Advanced Technology,Chinese Academy of Sciences,Shenzhen 518055,China
6. State Key Laboratory of Fine Chemicals,College of Materials Science and Engineering,Shenzhen University,Shenzhen 518060,China
7. Cancer Center,Institute of Translational Medicine,Faculty of Health Sciences,University of Macau,Macau 999078,China
8. School of Chemical Engineering,Northwest University,Xi'an 710069,China
折叠

Abstract

Carbon monoxide(CO)is a vital intracellular gas messenger known for its cytoprotective and homeostatic properties.It plays a pivotal role in a myriad of biological processes.Therefore,the precise detection of CO is of paramount importance in unraveling the intricacies of pathological mechanisms and advancing the development of disease diagnosis.We herein introduce NFCOP,a state-of-the-art near-infrared(NIR)turn-on fluorescence(FL)probe that has been meticulously designed for highly sensitive,swift and se-lective imaging of CO.The NFCOP response occurred rapidly with CO,within just 10 s,and the calculated detection limit for CO was determined to be 0.32 μmol/L.Further investigations conducted at the cellular level and in vivo demonstrated that NFCOP possesses high sensitivity and selectivity for imaging CO.

Key words

Palladium-free/Chemoselective probe/Fluorescence imaging/Carbon monoxide/Near-infrared

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出版年

2024

中国化学快报(英文版)

中国化学会

中国化学快报(英文版)

CSTPCDCSCD

影响因子：0.771

ISSN：1001-8417

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