首页|Palladium-free chemoselective probe for in vivo fluorescence imaging of carbon monoxide

Palladium-free chemoselective probe for in vivo fluorescence imaging of carbon monoxide

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Carbon monoxide(CO)is a vital intracellular gas messenger known for its cytoprotective and homeostatic properties.It plays a pivotal role in a myriad of biological processes.Therefore,the precise detection of CO is of paramount importance in unraveling the intricacies of pathological mechanisms and advancing the development of disease diagnosis.We herein introduce NFCOP,a state-of-the-art near-infrared(NIR)turn-on fluorescence(FL)probe that has been meticulously designed for highly sensitive,swift and se-lective imaging of CO.The NFCOP response occurred rapidly with CO,within just 10 s,and the calculated detection limit for CO was determined to be 0.32 μmol/L.Further investigations conducted at the cellular level and in vivo demonstrated that NFCOP possesses high sensitivity and selectivity for imaging CO.

Palladium-freeChemoselective probeFluorescence imagingCarbon monoxideNear-infrared

Gongcheng Ma、Qihang Ding、Yuding Zhang、Yue Wang、Jingjing Xiang、Mingle Li、Qi Zhao、Saipeng Huang、Ping Gong、Jong Seung Kim

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Guangdong Key Laboratory of Nanomedicine,Shenzhen Engineering Laboratory of Nanomedicine and Nanoformulations,CAS-HK Joint Lab for Biomaterials,Research Laboratory for Biomedical Optics and Molecular Imaging,Shenzhen Key Laboratory for Molecular Imaging,CAS Key Lab for Health Informatics,Shenzhen Institutes of Advanced Technology,Chinese Academy of Sciences,Shenzhen 518055,China

University of Chinese Academy of Sciences,Beijing 100049,China

Department of Chemistry,Korea University,Seoul 02841,South Korea

School of Chemical Engineering,Northwest University,Xi'an 710069,China

Cancer Center,Institute of Translational Medicine,Faculty of Health Sciences,University of Macau,Macau 999078,China

State Key Laboratory of Fine Chemicals,College of Materials Science and Engineering,Shenzhen University,Shenzhen 518060,China

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2024

中国化学快报(英文版)
中国化学会

中国化学快报(英文版)

CSTPCD
影响因子:0.771
ISSN:1001-8417
年,卷(期):2024.35(9)