首页|Inhaled multilevel size-tunable,charge-reversible and mucus-traversing composite microspheres as trojan horse:Enhancing lung deposition and tumor penetration
Inhaled multilevel size-tunable,charge-reversible and mucus-traversing composite microspheres as trojan horse:Enhancing lung deposition and tumor penetration
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Dry powder inhalation represents a promising approach for the treatment of lung cancer,offering sev-eral advantages such as enhanced targeting,improved bioavailability,and reduced toxicity.However,tra-ditional dry powder formulations suffer from limitations,notably low pulmonary delivery efficiency and inadequate penetration into tumor tissues,thereby limiting their therapeutic efficacy.In response to these challenges,we have developed an innovative trojan horse strategy,harnessing an inhalable nanoparticle-in-microsphere system characterized by tunable size,reversible charge,and mucus-penetrating capa-bilities.The inhalable nanoparticle-in-microsphere system exhibit stable structural properties,excellent environmental responsiveness and high biocompatibility.More importantly,the therapeutic effect of MTX@PAMAM@HA@Gel(MPHG)was demonstrated in vitro and in vivo.This system offers improved pul-monary delivery efficiency,enhanced drug retention within tumor tissues,and effective penetration,thus representing a promising strategy in lung cancer treatment.
Pulmonary deliverySize-tunable nanoparticlesCharge-reversible nanoparticlesMucus penetrationLung cancer
Lishan Xiong、Xinyuan Li、Xiaojie Lu、Zhendong Zhang、Yan Zhang、Wen Wu、Chenhui Wang
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Chongqing Key Laboratory of Natural Product Synthesis and Drug Research,School of Pharmaceutical Sciences,Chongqing University,Chongqing 401331,China
Chongqing Key Laboratory of High Active Traditional Chinese Drug Delivery System,Chongqing Engineering Research Center of Pharmaceutical Sciences,Chongqing Medical and Pharmaceutical College,Chongqing 404120,China
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