Utilizing dual-responsive iridium(Ⅲ)complex for hepatocellular carcinoma:Integrating photoacoustic imaging with chemotherapy and photodynamic therapy

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外文摘要：Stimuli-triggered release and alleviating resistance of iridium(Ⅲ)-based drugs at tumor sites re-mains challengeable for clinical hepatoma therapy.Herein,a doxorubicin@iridium-transferrin(DOX@Ir-TF)nanovesicle was synthesized by carboxylated-transferrin(TF)and doxorubicin-loaded amphiphilic iridium-amino with quaternary ammonium(QA)groups and disulfide bonds.The QA groups enhanced photophysical properties and broadened production capacity of photoinduced-reactive oxygen species(ROS),while the disulfide-bridged bonds regulated oxidative stress levels through reacting with glu-tathione(GSH);simultaneously,modification of TF improved recognition and endocytosis of the nanovesi-cle for tumor cells.Based on in-vitro results,a controlled-release behavior of DOX upon a dual-responsiveness of GSH and near-infrared ray(NIR)irradiation was presented,along with high-efficiency generation of ROS.After an intravenous injection,the nanovesicle was targeted at tumor sites,realizing TF-navigated photoacoustic imaging guidance and synergistic chemotherapy-photodynamic therapy under NIR/GSH stimulations.Overall,newly-synthesized DOX@Ir-TF nanovesicle provided a potential in subcuta-neous hepatocellular carcinoma therapy due to integrations of targeting delivery,dual-stimuli responsive release,synergistic therapy strategy,and real-time monitoring.

外文关键词：

Amphiphilic iridium complexTransferrin targetingNIR/GSH dual-responsivenessPhotoacoustic imagingSynergistic tumor therapy

作者：

Jinyu Guo、Yandai Lin、Shaohua He、Yueqing Chen、Fenglu Li、Renjie Ruan、Gaoxing Pan、Hexin Nan、Jibin Song、Jin Zhang

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作者单位：

Qingyuan Innovation Laboratory,Quanzhou 362801,China

College of Chemical Engineering,Fuzhou University,Fuzhou 350108,China

Department of Pediatric Surgery,Shengli Clinical Medical College of Fujian Medical University,Fuzhou 350001,China

MOE Key Laboratory for Analytical Science of Food Safety and Biology,State Key Laboratory of Photocatalysis on Energy and Environment,College of Chemistry,Fuzhou University,Fuzhou 350108,China

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出版年：

2024

DOI：

10.1016/j.cclet.2024.109537

中国化学快报(英文版)

中国化学会

中国化学快报(英文版)

CSTPCD

影响因子：0.771

ISSN：1001-8417

年,卷(期)：2024.35(9)