Abstract
In this work,we established an exceptionally facile method for the preparation of Ni-CeO2 nanorods in a kind of deep eutectic solvents(DESs)composed of L-proline and Ce(NO3)3-6H2O.First,Ni-CeO2 nanorods were successfully prepared by adding Ni(NO3)3-6H2O to DESs.Then,we found that Ni-CeO2 nanorods prepared in DESs have more prominent oxidase-like activity than pure CeO2.The outstanding catalytic activity of Ni-CeO2 could be ascribed to its high Ce3+/Ce4+ratio.As a proof-of-concept application,the Ni-CeO2 nanorods were successfully acted as a colorimetric platform for the sensitive determination of ascorbic acid and α-glucosidase activity,which displays excellent analytical performance.Moreover,this sensing platform was applied for screening natural α-glucosidase inhibitors,such as terpenoids from nat-ural products.The results indicated that ursolic acid and oleanolic acid had good inhibitory rates.This strategy not only provides a new way to construct more kinds of nanomaterials from DESs,but also of-fers a facile and effective tool to screen the α-glucosidase natural inhibitors as potential anti-diabetic drugs.
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