首页|Colorimetric detection of α-glucosidase activity using Ni-CeO2 nanorods and its application to potential natural inhibitor screening
Colorimetric detection of α-glucosidase activity using Ni-CeO2 nanorods and its application to potential natural inhibitor screening
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In this work,we established an exceptionally facile method for the preparation of Ni-CeO2 nanorods in a kind of deep eutectic solvents(DESs)composed of L-proline and Ce(NO3)3-6H2O.First,Ni-CeO2 nanorods were successfully prepared by adding Ni(NO3)3-6H2O to DESs.Then,we found that Ni-CeO2 nanorods prepared in DESs have more prominent oxidase-like activity than pure CeO2.The outstanding catalytic activity of Ni-CeO2 could be ascribed to its high Ce3+/Ce4+ratio.As a proof-of-concept application,the Ni-CeO2 nanorods were successfully acted as a colorimetric platform for the sensitive determination of ascorbic acid and α-glucosidase activity,which displays excellent analytical performance.Moreover,this sensing platform was applied for screening natural α-glucosidase inhibitors,such as terpenoids from nat-ural products.The results indicated that ursolic acid and oleanolic acid had good inhibitory rates.This strategy not only provides a new way to construct more kinds of nanomaterials from DESs,but also of-fers a facile and effective tool to screen the α-glucosidase natural inhibitors as potential anti-diabetic drugs.
Xinjiang Uygur Autonomous Product Quality Supervision and Inspection Institute,Urumqi 830000,China
CAS Key Laboratory of Chemistry of Northwestern Plant Resources and Key Laboratory for Natural Medicine of Gansu Province,Lanzhou Institute of Chemical Physics,Chinese Academy of Sciences,Lanzhou 730000,China
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