Abstract
Reactive oxygen species(ROS)are essential in various pathological and physiological processes.Develop-ing nanosystems that generate ROS in a controlled manner is of great interest for nanomedicine.DNA nanotechnology offers a promising approach to constructing programmable ROS-generating platforms.By incorporating photosensitizers or metal ions,DNA nanostructures can be designed to produce ROS in a spatially and temporally desired fashion.DNA-based ROS-generating nanosystems hold great potential in intracellular homeostasis regulation,drug release,and cancer therapy.This review summarizes recent advances in developing DNA-based ROS-generating nanosystems,highlights their emerging biomedical applications,and discusses the opportunities and challenges for further applications.DNA nanotechnol-ogy provides a versatile toolkit to construct biocompatible ROS-generating platforms for next-generation nanomedicines.
维普
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