首页|Research advances of tetrahedral framework nucleic acid-based systems in biomedicine
Research advances of tetrahedral framework nucleic acid-based systems in biomedicine
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This article reviews the latest research advances of tetrahedral framework nucleic acid(tFNA)-based sys-tems in their fabrication,modification,and the potential applications in biomedicine.TFNA arises from the synthesis of four single-stranded DNA chains.Each chain contains brief sequences that complement those found in the other three,culminating in the creation of a pyramid-shaped nanostructure of ap-proximately 10 nanometers in size.The first generation of tFNA demonstrates inherent compatibility with biological systems and the ability to permeate cell membrane effectively.These attributes translate into remarkable capabilities for regulating various cellular biological processes,fostering tissue regeneration,and modulating immune responses.The subsequent evolution of tFNA introduces enhanced adaptability and a relatively higher degree of biological stability.This advancement encompasses structural modifica-tions,such as the addition of functional domains at the vertices or side arms,integration of low molec-ular weight pharmaceuticals,and the implementation of diverse strategies aimed at reversing multi-drug resistance in tumor cells or microorganisms.These augmentations empower tFNA-based systems to be utilized in different scenarios,thus broadening their potential applications in various biomedical fields.
DNA nanomaterialsTetrahedral framework nucleic acidDrug deliveryAntioxidationImmunomodulationTissue regenerationAntitumor therapy
Lihang Wang、Mary Li Javier、Chunshan Luo、Tingsheng Lu、Shudan Yao、Bing Qiu、Yun Wang、Yunfeng Lin
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Department of Spine Surgery,Beijing Jishuitan Hospital Guizhou Hospital,Guiyang 550014,China
State Key Laboratory of Oral Diseases,National Center for Stomatology,National Clinical Research Centre for Oral Diseases,West China Hospital of Stomatology,Sichuan University,Chengdu 610041,China
Sichuan Provincial Engineering Research Center of Oral Biomaterials,Chengdu 610041,China
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