Abstract
Aliphatic C(sp3)-H moieties are ubiquitous in numerous organic compounds.Direct functionalization of inert C(sp3)-H bonds is a powerful and straightforward approach for the efficient construction of diverse carbon-carbon or carbon-heteroatom bonds.Chelating group directed metal-catalyzed remote function-alization of readily available alkenes has emerged as an appealing strategy for rapidly accessing various value-added aliphatic molecules.With the aid of directing groups,various α-,β-and y-functionalized alkanes could be synthesized smoothly with excellent regioselectivity.The preferred formation of a sta-ble five-or six-membered metallacycle intermediate terminates the chain-walking at a specific methylene site,which serves as the driving force for excellent site-selective migratory functionalization.This review herein is aimed at summarizing the recent progress on the metal-catalyzed regiodivergent functionaliza-tion of unactivated alkenes by merging alkene isomerization and cross-coupling with the assistance of directing auxiliary.Last but not least,the current situations and future directions in this field are high-lighted and discussed.
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