首页|Enhancing self-assembly efficiency of macrocyclic compound into nanotubes by introducing double peptide linkages
Enhancing self-assembly efficiency of macrocyclic compound into nanotubes by introducing double peptide linkages
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Constructing more stable self-assembled organic nanotubes has been one of the focuses of scientists in recent decades.Hexakis(m-phenylene ethynylene)(m-PE)benzene macrocycles can form stable tubular self-assemblies in nonpolar or weakly polar solvents through the π-π interaction of the main skeleton and the hydrogen bonding of the side chain amide.We covalently linked two macrocyclic units at the para position of the macrocycles using two oligo(β-alanine)linkers through an efficient synthetic route.UV-visible spectroscopy,fluorescence spectroscopy,and circular dichroism spectroscopy were employed to demonstrate that the incorporation of two peptide chains significantly enhances the stability of the self-assemblies.Meanwhile,the average open time of the ion channel formed by the macrocyclic dimer in the lipid bilayer was significantly better than that of the ion channel formed by a single macrocycle.This study shows that this strategy effectively improves the efficiency of self-assembly and the stability of its formed self-assemblies,providing a feasible strategy for constructing organic self-assembled nanotubes in highly polar solvents.
Macrocyclic compoundsSupramolecular assemblyIon transportationSynthetic ion channelsMolecular nanotubes
Cheng-Yan Wu、Yi-Nan Gao、Zi-Han Zhang、Rui Liu、Quan Tang、Zhong-Lin Lu
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College of Chemistry,Beijing Normal University,Beijing 100875,China
College of Chemistry and Materials Engineering,Bohai University,Jinzhou 121013,China
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