Copper-catalyzed photoredox 1,4-amidocyanation of 1,3-enynes with N-amidopyridin-1-ium salts and TMSCN:Facile access to α-amido allenyl nitriles

Liangfeng Yang ¹Liang Zeng ¹Yanping Zhu ²Qiuan Wang ³Jinheng Li⁴

扫码查看

作者信息

1. State Key Laboratory of Chemo/Biosensing and Chemometrics,Hunan University,Changsha 410082,China;State Key Laboratory Base of Eco-Chemical Engineering,College of Chemical Engineering,Qingdao University of Science and Technology,Qingdao 266042,China
2. School of Pharmacy,Key Laboratory of Molecular Pharmacology and Drug Evaluation,Ministry of Education,Collaborative Innovation Center of Advanced Drug Delivery System and Biotech Drugs in Universities of Shandong,Yantai University,Yantai 264005,China
3. State Key Laboratory of Chemo/Biosensing and Chemometrics,Hunan University,Changsha 410082,China
4. State Key Laboratory of Chemo/Biosensing and Chemometrics,Hunan University,Changsha 410082,China;State Key Laboratory Base of Eco-Chemical Engineering,College of Chemical Engineering,Qingdao University of Science and Technology,Qingdao 266042,China;School of Pharmacy,Key Laboratory of Molecular Pharmacology and Drug Evaluation,Ministry of Education,Collaborative Innovation Center of Advanced Drug Delivery System and Biotech Drugs in Universities of Shandong,Yantai University,Yantai 264005,China;State Key La
折叠

Abstract

A new 1,4-amidocyanation of 1,3-enynes with N-amidopyridin-1-ium salts and TMSCN using a copper and photoredox synergetic catalysis for producing α-amido allenyl nitriles is developed.Employing N-amidopyridin-1-ium salts as the amidyl radical precursors,the reaction enables the formation of two new bonds,one C(sp3)-N bond and one C(sp2)-C(sp)bond,in a single reaction step.This reaction represents a mild,general route to the construction of the α-amido allenyl nitrile architectures,which characterizes a broad scope,a good functional group compatibility and an excellent selectivity.

Key words

Copper/Photoredox catalysis/Amidocyanation/N-(Sulfonamido)pyridin-1-ium salts/1,3-Enynes/α-Sulfonamido allenyl nitriles

引用本文复制引用

出版年

2024

中国化学快报(英文版)

中国化学会

中国化学快报(英文版)

CSTPCDCSCD

影响因子：0.771

ISSN：1001-8417

段落导航