首页|Cancer cell membrane camouflaged biomimetic gelatin-based nanogel for tumor inhibition

Cancer cell membrane camouflaged biomimetic gelatin-based nanogel for tumor inhibition

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Enhancing the active tumor targeting ability and decreasing the clearance of reticuloendothelial system(RES)are important issues for drug delivery systems(DDSs)in cancer therapy.In recent years,cell mem-brane camouflage,as one of the biomimetic modification strategies,has shown huge potential.Many nat-ural properties of source cells can be inherited,allowing the DDSs to successfully avoid phagocytosis by macrophages,prolong circulation time,and achieve homologous targeting to lesion tissue.In this study,a cancer cell membrane camouflaged nanoplatform based on gelatin with a typical core-shell structure was developed for cancer chemotherapy.Doxorubicin(DOX)loaded gelatin nanogel(NG@DOX)acted as the inner core,and 4T1(mouse breast carcinoma cell)membrane was set as the outer shell(M-NG@DOX).The M-NG platform enhanced the ability of homologous targeting due to the surface protein of cell mem-brane being completely retained,which could promote the cell uptake of homotypic cells,avoid phagocy-tosis by RAW264.7 macrophages,and therefore increase accumulation in tumor tissue.Meanwhile,due to the better controlled drug release capability of M-NG@DOX,premature release of DOX in circulation could be reduced,minimizing side effects in common chemotherapy.As a result,the biomimetic nanoplatform in this study,obtained by a cancer cell membrane camouflaged drug delivery system,efficiently reached desirable tumor elimination,providing a significant strategy for effective targeted therapy and specific carcinoma therapy.

Cell membrane camouflageBiomimeticGelatin nanogelDrug deliveryTumor therapy

Yuanzheng Wang、Chen Zhang、Shuyan Han、Xiaoli Kong、Changyun Quan、Jun Wu、Wei Zhang

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Department of Orthopedics,Guizhou Provincial People's Hospital,Guiyang 550000,China

Guangdong Provincial Key Laboratory of Sensor Technology and Biomedical Instruments(Sun Yat-sen University),School of Biomedical Engineering,Sun Yat-sen University,Guangzhou 510006,China

Department of Nephrology,Center of Kidney and Urology,The Seventh Affiliated Hospital,Sun Yat-sen University,Shenzhen 518107,China

Bioscience and Biomedical Engineering Thrust,The Hong Kong University of Science and Technology(Guangzhou),Guangzhou 511400,China

Division of Life Science,The Hong Kong University of Science and Technology,Hong Kong SAR 999077,China

Department of Outpatient,The First Affiliated Hospital of Sun Yat-sen University,Guangzhou 510080,China

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2024

10.1016/j.cclet.2024.109578

中国化学快报(英文版)
中国化学会

中国化学快报(英文版)

CSTPCD
影响因子：0.771
ISSN：1001-8417
年,卷(期)：2024.35(11)