首页|A β-lactamase-activatable photosensitizer for the treatment of resistant bacterial infections
A β-lactamase-activatable photosensitizer for the treatment of resistant bacterial infections
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Antibacterial agent of activatable photosensitizer not only has the advantages of traditional photosensi-tizers,such as good curative effect and low resistance,but also has better selectivity for bacteria and lower toxicity to normal tissues.Limited reports of activatable photosensitizer can be used to treat drug-resistant bacteria.In order to meet this challenge,we designed and synthesized an activatable photo-sensitizer(Ce-OHOA),which can not only selectively identify methicillin-resistant Staphylococcus aureus(MRSA)with high expression of β-lactamase by fluorescence imaging,but also kill MRSA with less than 10 times the concentration and 10 times the irradiation dose of CySG-2 reported.Ce-OHOA not only com-bines the dual functions of fluorescence diagnosis and photodynamic therapy,but also selectively acts on bacteria with high expression of β-lactamase and has little toxicity to normal cells.We expect that the study of this activating photosensitizer will provide a new solution for antibacterial photodynamic ther-apy(aPDT)of drug-resistant bacteria.
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