Tetrahedron DNA nanostructure/iron-based nanomaterials for combined tumor therapy

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外文摘要：Triple-negative breast cancer,due to its aggressive nature and lack of targeted treatment,faces serious challenges in breast cancer treatment.Conventional therapies,such as chemotherapy,are encumbered by a range of limitations,and there is an urgent need for more effective treatment strategies.Ferroptosis,as an iron-dependent form of cell death,has exhibited promising potential in cancer treatment.Combining ferroptosis with other cancer therapies offers new avenues for treatment.Tetrahedral DNA nanostruc-ture(TDN),a novel DNA-based three-dimensional(3D)nanomaterial,is promising drug delivery vehicle and can be utilized for functionalizing inorganic nanomaterials.In this work,we have demonstrated the preparation of Fe3O4-PEI@TDN-DOX nanocomposites and elucidated their antitumor mechanism.The TDN facilitated the enhanced cellular uptake of polyetherimide(PEI)-modified Fe3O4,and the delivery of the chemotherapeutic drug doxorubicin(DOX)further augmented their anti-tumor effect.This novel strategy can destroy the tumor redox homeostasis and produce overwhelming lipid peroxides,consequently sen-sitizing the tumor to ferroptosis.The integration of ferroptosis with other cancer therapies opens up new possibilities for treatment.This research provides valuable mechanistic insights and practical strategies for leveraging nanotechnology to induce ferroptosis and amplify its impact on tumor cells.

外文关键词：

Tetrahedron DNA nanostructureFerroptosisDoxorubicinBreast cancerCombined cancer therapy

作者：

Jiangshan Xu、Weifei Zhang、Zhengwen Cai、Yong Li、Long Bai、Shaojingya Gao、Qiang Sun、Yunfeng Lin

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作者单位：

College of Biomedical Engineering,Sichuan University,Chengdu 610065,China

State Key Laboratory of Oral Diseases,National Center for Stomatology,National Clinical Research Center for Oral Diseases,West China Hospital of Stomatology,Sichuan University,Chengdu 610041,China

Department of Orthopedics,Orthopedic Research Institute,West China Hospital,Sichuan University,Chengdu 610041,China

Department of Oral Implantology,The Affiliated Stomatological Hospital of Southwest Medical University,Luzhou 646000,China

Sichuan Provincial Engineering Research Center of Oral Biomaterials,Chengdu 610041,China

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出版年：

2024

DOI：

10.1016/j.cclet.2024.109620

中国化学快报(英文版)

中国化学会

中国化学快报(英文版)

CSTPCD

影响因子：0.771

ISSN：1001-8417

年,卷(期)：2024.35(11)