摘要
目的 探索年龄/胸腔积液腺苷脱氨酶(年龄/ADA)、血清乳酸脱氢酶/胸腔积液腺苷脱氨酶(Cancer Ratio,CR)诊断恶性胸腔积液(MPE)的临床价值.方法 收集44例MPE和48例良性胸腔积液(BPE),比较两组研究对象年龄、性别、常规肿瘤标志物癌胚抗原(CEA)、年龄/ADA和CR的差异;绘制受试者工作特征(ROC)曲线,计算CEA、年龄/ADA和CR的ROC曲线下面积(AUC)、敏感性和特异性,比较三者单独或联合诊断MPE的效能.结果 CEA、年龄/ADA和CR在MPE组较BPE组显著升高(P＜0.05);CEA、年龄/ADA和CR诊断MPE的AUC分别为0.768、0.837、0.866,敏感性分别为61.36％、88.64％、81.82％,特异性分别为85.42％、75.00％、83.33％;CEA+年龄/ADA、CEA+CR、年龄/ADA+CR、CEA+年龄/ADA+CR 对应的 AUC 分别为 0.892、0.911、0.837、0.907,敏感性分别为 81.82％、86.36％、88.64％、90.91％,特异性分别为 79.17％、79.17％、75.00％、77.08％.结论 年龄/ADA和CR对于MPE具备良好的诊断效能,联合常规肿瘤标志物CEA可进一步提高诊断效能,未来还需要更多的研究去探索其诊断价值.
Abstract
Objective To explore the clinical value of age/pleural fluid adenosine deaminase(age/ADA)ratio and serum lactate dehydrogenase/pleural fluid adenosine deaminase ratio(Cancer Ratio,CR)in the diagnosis of malignant pleural effusions(MPE).Methods The study collected 44 patients with MPE and 48 patients with benign pleural effusion(BPE)to compare the differences in age,gender,carcinoembryonic antigen(CEA),age/ADA ratio and CR between the groups.The receiver operating characteristic(ROC)curve of CEA,age/ADA and CR was constructed and the area under the ROC curve(AUC),sensitivity and specificity was calculated to identify the diagnostic performance of the three indicators alone or in combination in MPE.Results CEA,age/ADA and CR were significant higher in the MPE group than those in the BPE group(all P＜0.05),the AUCs of CEA,age/ADA and CR were 0.768,0.837 and 0.866,respectively;the sensitivity was 61.36％,88.64％and 81.82％,the specificity was 85.42％,75.00％,83.33％,respectively.The AUCs of CEA combined with age/ADA,CEA combined with CR,age/ADA combined with CR,CEA combined with age/ADA and CR were respectively 0.892,0.911,0.837 and 0.907;the sensitivity was 81.82％,86.36％,88.64％and 90.91％,the specificity was 79.17％,79.17％,75.00％and 77.08％,respectively.Conclusions Age/ADA and CR demonstrated good diagnostic performance in MPE,moreover,the diagnostic performance can be further improved when combined with the traditional tumor marker CEA,and more research about its diagnostic value is needed in the future.
基金项目
四川省重点研发计划(2020YFS0147)
四川大学华西医院临床研究孵化项目(2019HXFH042)
NETL
NSTL
万方数据