首页|基于改良版咳嗽评估问卷对慢性咳嗽病因诊断的简单决策树模型研究

基于改良版咳嗽评估问卷对慢性咳嗽病因诊断的简单决策树模型研究

The simple decision tree for etiologic diagnosis of chronic cough based on the Modified Cough Assessment Test

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目的 比较不同病因慢性咳嗽患者的临床表现,建立改良版咳嗽评估问卷和简单决策树模型提高病因诊断效能.方法 收集同济医院呼吸与危重症医学科门诊2021年10月-2023年8月期间诊断明确的慢性咳嗽患者的临床资料,依据病因诊断将患者分为激素敏感性咳嗽(corticosteroid-responsive cough,CRC)、上气道咳嗽综合征(upper airway cough syndrome,UACS)和胃食管反流性咳嗽(gastroesophageal reflux-related cough,GERC)三组,各组患者均完成咳嗽问卷,探究咳嗽问卷各问题是否为慢性咳嗽病因的危险因素,统计分析后依据结果建立改良版咳嗽评估问卷(modified cough assessment test,MCET),并构建慢性咳嗽病因诊断与鉴别诊断的简单决策树模型.结果 共纳入358例单一病因的慢性咳嗽患者,其中CRC组201例(56.1%)、UACS组125例(34.9%)、GERC组32例(8.94%).问卷中问题"咳嗽伴有喘息或胸闷"[比值比(odds ratio,OR)=3.222,95%置信区间(confidential interval,CI)2.144~4.843,P<0.001]、"咳嗽呈现昼重夜轻"(OR=1.755,95%CI 1.264~2.435,P<0.001)以及"咳嗽伴有反酸烧心或消化不良"(OR=15.580,95%CI5.894~41.184,P<0.001)分别是各组慢性咳嗽对应病因的独立危险因素.新建立的MCET对各组慢性咳嗽病因诊断的受试者操作特征曲线下面积分别为0.871、0.840和0.988,均优于中文版莱切斯特咳嗽问卷(0.792、0.766和0.913)和简易咳嗽程度评分表(Cough Evaluation Test,CET)(0.649、0.691 和 0.580),除 CET 诊断 GERC 外(P=0.134),均 P<0.05.针对慢性咳嗽病因鉴别诊断建立的简单决策树模型的准确率为77.4%.结论 基于改良版咳嗽评估问卷建立的简单决策树模型能够简单快速地鉴别慢性咳嗽病因,可作为提高门诊慢性咳嗽临床诊治效能的工具.
Objective To compare the clinical characteristics of chronic cough,and to establish the Modified Cough Assessment Test and the simple decision tree to improve the efficacy of etiologic diagnosis.Methods Patients with chronic cough consulted in Tongji Hospital between October 2021 and August 2023 were enrolled in our study.The patients with identified single cause were divided into 3 groups accordingly:corticosteroid-responsive cough(CRC),upper airway cough syndrome(UACS)and gastroesophageal reflux-related cough(GERC).And the characteristics of chronic cough in different causes were assessed and compared by cough questionnaires.Independent predictors of various causes were identified by multivariate logistic regression analysis and used to establish the Modified Cough Assessment Test(MCET)and to construct the simple decision tree.Results A total of 358 patients were enrolled,including 201 with CRC(56.1%),125 with UACS(34.9%)and 32 with GERC(8.94%)."Cough with wheezing or chest tightness"(OR=3.222,95%CI 2.144-4.843,P<0.001),"Cough with daytime heaviness and nighttime lightness"(OR=1.755,95%CI 1.264-2.435,P<0.001),and"Cough with acid reflux,heartburn or indigestion"(OR=15.580,95%CI 5.894-41.184,P<0.0O1)were independent factors for each group,respectively.The area under ROC curve for classification of CRC,UACS and GERC were 0.871,0.840 and 0.988 for MCET,which were better than those of Leicester Cough Questionnaire(LCQ)(0.792,0.766 and 0.913)and Cough Evaluation Test(CET)(0.649,0.691 and 0.580).The accuracy of the simple decision tree for the differential diagnosis of chronic cough was 77.4%.Conclusion The simple decision tree based on the Modified Cough Evaluation Test is a simple and effective method of etiologic diagnosis of chronic cough,which can be used as a tool to improve the efficacy of clinical diagnosis in outpatient settings.

Chronic coughcough questionnaireetiologydecision tree

贾林杰、柏佳、马佳琪、倪望、余慕清、赵建平、周敏

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华中科技大学同济医学院附属同济医院呼吸与危重症医学科(湖北武汉 430030)

重庆市渝中区大坪医院心血管内科(重庆 400000)

慢性咳嗽 咳嗽问卷 病因 决策树

国家自然科学基金青年基金

81700032

2024

中国呼吸与危重监护杂志
四川大学华西医学中心,四川大学华西医院

中国呼吸与危重监护杂志

CSTPCD
影响因子:1.306
ISSN:1671-6205
年,卷(期):2024.23(3)
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