慢性阻塞性肺疾病患者认知障碍患病率的Meta分析
Prevalence of cognitive impairment in patients with chronic obstructive pulmonary disease:a meta-analysis
朱洁云 1何翠影 2陆钊 1叶长广 3蔡昭强 3黄春莉 1潘冬赞 1沈印1
作者信息
- 1. 广西壮族自治区人民医院国际医疗部(广西南宁 530021)
- 2. 广西医科大学(广西南宁 530021)
- 3. 合浦县人民医院呼吸与危重症医学科(广西合浦 536100)
- 折叠
摘要
目的 系统分析慢性阻塞性肺疾病(chronic obstructive pulmonary disease,COPD,简称慢阻肺)患者认知障碍的患病率.方法 计算机检索PubMed、Embase、中国知网(CNKI)、万方数据库和维普网(VIP)数据库,筛选关于慢阻肺患者认知障碍患病情况相关的临床研究,检索时限均为建库至2023年5月3日.由2名研究员独立进行文献筛选、资料提取和纳入研究的偏倚风险评估,采用Stata16.0软件进行Meta分析.结果 共纳入40个研究,共计9 988例慢阻肺患者.随机效应模型Meta分析结果显示,慢阻肺患者认知障碍的患病率为48.26％[95％CI(42.39％,54.20％)].亚组分析结果显示,慢阻肺急性加重期患者认知障碍的患病率高于稳定期患者(58.62％vs.49.71％);2015年前的患病率较低,2015-2019年间和2020-2023年间慢阻肺患者认知障碍的患病率较高,依次为29.07％、53.06％和48.26％;国内慢阻肺患者认知障碍的患病率明显高于国外患者(52.66％vs.37.06％).结论 慢阻肺患者认知障碍的患病率较高,对慢阻肺患者应加强认知障碍的筛查力度,早期评估和干预治疗.
Abstract
Objective To systematically analyze the prevalence of cognitive impairment in patients with COPD.Methods An electronic search in PubMed,Embase,CNKI,WanFang Data and VIP databases to identify studies describing the prevalence of cognitive impairment in patients with COPD from inception to 3 May 2023.Two reviewers independently screened literature,extracted data and assessed the risk of bias of included studies,then,the meta-analysis was performed by using Stata16.0 software.Results A total of 40 studies involving 9,988 patients with COPD were included.Meta-analysis showed that the total prevalence of cognitive impairment in patients with COPD was 48.26％(95％CI 42.39％to 54.20％).The results of subgroup analysis revealed that the prevalence of cognitive impairment in patients with acute exacerbation of COPD was higher than that in patients with stable-phase(58.62％vs.49.71％).The prevalence of cognitive impairment in COPD patients was 29.07％before 2015,while the prevalence between 2015-2019 and 2020-2023 were higher,with rates of 53.06％and 48.26％respectively.The prevalence of cognitive impairment in domestic COPD patients was significantly higher than that in foreign patients(52.66％vs.37.06％).Conclusion The prevalence of cognitive impairment is relatively high in COPD patients,highlighting the need to strengthen the screening for cognitive impairment in COPD patients and provide early assessment and intervention.
关键词
慢性阻塞性肺疾病/认知障碍/患病率/Meta分析Key words
Chronic obstructive pulmonary disease/Cognitive impairment/Prevalence/Meta-analysis引用本文复制引用
基金项目
广西重点研发计划(桂科AB23026019)
出版年
2024
NETL
NSTL
万方数据