Objective To evaluate the relationship between CT lesion changes in CO VID-19 patients and different subgroups of T lymphocytes,providing reference information for assessing patient conditions,predicting outcomes,and evaluating treatment efficacy.Methods Clinical and imaging data of confirmed COVID-19 patients admitted to the Chongqing Public Health Medical Center from January 24 to March 15,2020,were collected.Based on the absorption characteristics of lesions in CT images,patients were categorized into three groups:Group A(obviously continuously absorbed),Group B(stable-slow absorption),and Group C(progressive absorption).The relationship between CT changes and T lymphocyte subgroups was analyzed according to lesion absorption.Results A total of 47 patients were included,with 18 in Group A,14 in Group B,and 15 in Group C.At different stages-admission,during treatment,and at the end of treatment-the levels of T lymphocytes were observed as follows:Group A＞Group B＞Group C.When lesions were absorbed,the average count of CD4+T lymphocytes was(544.43±163.34)cells/μl;when lesions showed little change or increased,CD4+T lymphocyte levels decreased to varying degrees.During treatment,both Group A and Group B showed CD4+T lymphocyte levels returning to above normal levels,with an average increase of 134 cells/μl in Group A,which was lower than that in Group B(192 cells/μl)and Group C(149 cells/μl).Finally,T lymphocyte levels reached normal in all groups,but Group A levels were higher than those in Groups B and C(P＜0.05).Upon follow-up,the average CD4+T lymphocyte count was(544.43±163.34)cells/μl in 52 cases of lesion absorption,(339.06±145.98)cells/μl in 31 cases of minimal change,and(230.50±95.24)cells/μl in 16 cases of lesion progression,with statistically significant differences among the three groups(P＜0.05).Conclusions The increase in lung lesions in patients indicates poor immune function,necessitating enhanced immune regulation.Conversely,if a decrease in T lymphocyte levels is detected during the course of the disease,attention should be given to the risk of lesion progression,and timely CT re-examinations should be conducted to monitor changes in lesions.
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