Objective To explore the clinical features,treatment measures,disease outcomes,and differences in patients with asthma admitted to hospitals in Qinghai and Tibetan Plateau,and further analyze the risk factors.Methods A retrospective analysis was conducted on the clinical data of 297 patients with asthma admitted to Qinghai Provincial People's Hospital and Tibet Autonomous Region People's Hospital from 2015 to 2021.A standardized case report form(CRF)was designed and used to collect patients'general information,International Classification of Diseases(ICD-10),clinical symptoms,treatment,laboratory examination,and pulmonary function test data.The clinical features of the patients were described,and the risk factors of the clinical features of asthma patients admitted to hospitals in Qinghai and Tibetan Plateau were analyzed by using a stepwise Logistic regression model.Results A total of 297 patients with asthma admitted to hospitals in Qinghai and Tibetan Plateau were included in this study.The overall pulmonary function of asthma patients admitted to hospitals in Qinghai was worse than that in Tibetan Plateau(FEV1/FVC％:73.22±13.59 vs.80.70±18.36,P＜0.001;TLC:101.50 vs.163.00,P=0.001).The incidence of related clinical symptoms in asthma patients admitted to hospitals in Qinghai were higher than those in Tibetan Plateau(dyspnea:98.0％vs.66.0％,P＜0.001;cyanosis:82.0％vs.34.0％,P＜0.001;pulmonary rales:80.7％vs.70.7％,P=0.046).There was no significant difference in treatment measures between patients in Qinghai and Tibetan Plateau(P＞0.05).The main factors contributing to the differences in clinical characteristics between the two regions were the altitude of residence(OR=0.94,95％CI:0.91-0.98,P=0.004)and the co-existence of allergic diseases(OR=9.47,95％CI:2.68-3 347.07,P=0.012).Conclusions Compared with Tibet,the incidence of asthma symptoms and poorer lung function were higher among inpatients with asthma in Qinghai;there was no significant difference in treatment measures between the two regions,but there was a significant difference in prognosis;the main factors contributing to the differences in clinical characteristics between the two regions were the altitude of residence and the co-existence of allergic diseases.
NETL
NSTL
万方数据
