Study on the chemical constituents from South China Sea soft coral Sinularia scabra and their bioactivities
Objective To investigate the chemical constituents and bioactivities of soft coral Sinularia scabra collected from South China Sea.Methods The isolation and purification of these compounds were performed by thin layer chromatography(TLC),silica gel,Sephadex LH-20 column chromatography and semi-preparative high performance liquid chromatography(HPLC).Their structures were characterized by analysis of NMR and MS data and comparison with the data reported in literature.Results Eighteen known compounds with diverse skeletons were isolated from the soft coral Sinularia scabra,including two sesquiterpenes:(E)-β-farnesene(1),β-elemene(2);six diterpenes:xiguscabrate A(3),19-hydroxylcembrene-C(4),xiguscabrate B(5),(11S,12S)-11,12-epoxycembrene-C(6),sinulariol C(7),isosarcophytoxide(8),nine norditerpenes:10-epi-gyrosanolide E(9),scabrolide D(10),scabrolide G(11),5-epi-sinuleptolide(12),sinuleptolide(13),gyrosanolide F(14),ineleganolide(15),scabrolide A(16),scabrolide B(17);one sterol:crassarosterol A(18).Conclusion Eighteen known compounds with diverse structural features were obtained from the title specimen.Compound 1 was isolated from the family Alcyoniidae for the first time,while compounds 2,9,12,13,15 and 18 were isolated from this species for the first time.In the immunosuppressive bioassay,compound 8 exhibited significant inhibitory against the proliferation of LPS-induced B cell(IC50=4.4 μmol/L).
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