Studies on secondary metabolites of sesquiterpenoids from a Xisha soft coral Lemnalia sp.
Objective To investigate the chemical structures of sesquiterpenoids isolated from a soft coral Lemnalia sp.collected from the Xisha islands.Methods The compounds in the soft coral crude extract were isolated and purified by TLC,silica gel column chromatography,MPLC and HPLC.Their structures were elucidated on the basis of NMR and MS spectroscopic data and by comparison with the data of literature.Results Ten sesquiterpenoids were isolated from Lemnalia sp.and were identified as lemnardosinane D(1),flavalin E(2),paralemnolin R(3),pathylactone A(4),(+)-13-hydroxy-aristlone(5),laevinone A(6),(+)-curcudiol(7),oplodiol(8),6-eudesmene-1β,4β-diol(9),paralemnolide A(10).Conclusion Ten known sesquiterpenoids with nardosinane,nornardosinane,aristolane,neolemnane,bisabolane,eudesmane and bisnorsesquiterpene-type skeletons were isolated from a soft coral Lemnalia sp..Compounds 4、5、7-10 were obtained from soft corals of the genus Lemnalia for the first time.
万方数据
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