Research on the ancient and modern application of marine traditional Chinese medicine endoconcha sepiae
Objective To explore the drug use experience and medication information of previous generations of clinicians contained in prescriptions containing endoconcha sepiae,analyze the ancient and modern applications of endoconcha sepiae,and provide basis for the rational clinical application of endoconcha sepiae and the development of related products.Methods Based on the 2020 edition of the first part of the"Pharmacopoeia of the People's Republic of China","Chinese Marine Materia Medica","Dictionary of Marine Traditional Chinese Medicine Prescriptions"and other herbal works and prescription books,the patent retrieval system of China National Intellectual Property Administration and China national knowledge infrastructure,Retrieve information related to prescriptions containing endoconcha sepiae and clinical research,and conduct frequency analysis,association rules analysis,bibliometric analysis and visualization processing.Results A total of 595 formulas containing endoconcha sepiae in the past dynasties were screened,and the data of modem endoconcha sepiae-containing clinical patent formulas were 364 items.Through analysis,it was found that in terms of compatibility,the compatibility frequency of ancient prescriptions and endoconcha sepiae,from high to low,was Angelica sinensis,Ossa draconis,Musk,Frankincense,Coptis chinensis,etc.;the compatibility frequency of modern prescriptions and endoconcha sepiae,from high to low,was Cynanchum otophyllum Schneid,Astragalus membranaceus,Atractylodes macrocephala Koidz.,etc.;in terms of indications,ancient prescriptions were often combined with warming herbs like dried ginger and aconite to treat sores;combined with the heat-clearing and detoxifying herbs Cochinchina Momordica Seed to treat metrorrhagia.Shellfish tooth and litharge,which are herbs for soothe the nerves and heat-clearing and detoxifying,are often used to treat pannus and eye diseases.In modem prescriptions,it is often combined with Cynanchum otophyllum Schneid,Radix Aucklandiae,Amomum villosum,etc.to treat chronic gastritis;Cynanchum otophyllum Schneid,Poria cocos and Taraxacum mongolicum are used to treat duodenal ulcer;Angelica sinensis,Rhizoma atractylodis and Coptis chinensis are used to treat gastric ulcer.Modem endoconcha sepiae clinical bibliometric analysis screened 703 endoconcha sepiae-containing clinical literature,which reached a peak in 2016 and became the focus of research on endoconcha sepiae treatment of gastroparesis after 2000.Conclusion The compositions and treatments of cuttlebone are different in ancient and modem times.In ancient times,endoconcha sepiae was mostly used with blood-activating drugs,and commonly used in bulk for the treatment of metrorrhagia,pannus,sores,eye diseases and so on.while in modem times,it is mostly used for the treatment of gastrointestinal diseases such as gastrointestinal ulcers,chronic gastritis,etc.Therefore,the clinical application of endoconcha sepiae and the research and development of its products should not only be inherited from the experience of the ancient doctors,but also be combined with the change of the disease spectrum in the modern times and the modem science and technology,and then be developed and applied in depth.
endoconcha sepiaemarine chinese medicinemedication analysisassociation rule
万方数据
维普
