Objective Total synthesis of notoamide E isolated from marine fungi.Methods The target product was synthesized by using some key steps such as selective bromination of indole at C-6,Miyaura boration,oxa-[3+3]cycloaddition reaction and so on.Results Total synthesis of notoamide E was achieved from cheap methyl L-tryptophanate hydrochloride in 9 steps(9.5％total yield).
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